Adenylate cyclase activity in homogenates of human melanoma cells. Effect of alpha-MSH and isoprenaline
DOI:
https://doi.org/10.2340/0001555569288291Abstract
The effects of the alpha-melanocyte-stimulating hormone (alpha-MSH) (10(-7)-10(-5) M) and the beta-adrenoceptor agonist isoprenaline (10(-9)-10(-4) M) on adenylate cyclase (AC) activity were investigated in homogenates of the human IGR 1 melanoma cells with or without additional GTP. Basal AC activity was increased by the administration of 10 microM GTP. Alpha-MSH had no effect on cyclic AMP (cAMP) accumulation, while isoprenaline stimulated AC activity in a dose-dependent manner.Downloads
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Copyright (c) 1989 E Karg, LH Johansson, A Hindemith-Augustsson, E Rosengren, H Rorsman
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