Injection-related Pain and the Benefit of a Syringe Pump for Dupilumab Adherence in Children with Atopic Dermatitis: a Retrospective Cross-sectional Study

Authors

  • Célia Delesalle Department of Pediatrics, Brest University Hospital, Brest, Brittany, France https://orcid.org/0009-0002-0265-8917
  • Aude Huitric Department of Pediatrics, Brest University Hospital, Brest, Brittany, France
  • Emilie Brenaut Department of Pediatrics, Brest University Hospital, Brest, Brittany, France; Department of Dermatology, Brest University Hospital, Brest, Brittany, France; University of Brest, LIEN, Brest, France
  • Laurent Misery Department of Pediatrics, Brest University Hospital, Brest, Brittany, France; Department of Dermatology, Brest University Hospital, Brest, Brittany, France; University of Brest, LIEN, Brest, France
  • Claire Abasq-Thomas Department of Pediatrics, Brest University Hospital, Brest, Brittany, France; Department of Dermatology, Brest University Hospital, Brest, Brittany, France; University of Brest, LIEN, Brest, France

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0553

Keywords:

atopic dermatitis, dupilumab, paediatrics, syringe pump, medical adherence, observational study

Downloads

Download data is not yet available.

References

Simpson EL, Lockshin B, Lee LW, Chen Z, Daoud M, Korotzer A. Real-world effectiveness of dupilumab in adult and adolescent patients with atopic dermatitis: 2-year interim data from the PROSE registry. Dermatol Ther 2024; 14: 261–270. DOI: https://doi.org/10.1007/s13555-023-01061-4

Lasek A, Bellon N, Mallet S, Puzenat E, Bursztejn AC, Abasq C, et al. Effectiveness and safety of dupilumab in the treatment of atopic dermatitis in children (6-11 years): data from a French multicentre retrospective cohort in daily practice. J Eur Acad Dermatol Venereol 2022; 36: 2423–2429. DOI: https://doi.org/10.1111/jdv.18450

Antalfy A, Berman K, Everitt C, Alten R, Latymer M, Godfrey CM. The adherence and outcomes benefits of using a connected, reusable auto-injector for self-injecting biologics: a narrative review. Adv Ther 2023; 40: 4758–4776. DOI: https://doi.org/10.1007/s12325-023-02671-2

Paller AS, Simpson EL, Siegfried EC, Cork MJ, Wollenberg A, Arkwright PD, et al. Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2022; 400: 908–919. DOI: https://doi.org/10.1016/S0140-6736(22)01539-2

Song J, Taraban M, Yu YB, Lu L, Guha Biswas P, Xu W, et al. In-situ biophysical characterization of high-concentration protein formulations using w NMR. MAbs 2024; 16. DOI: https://doi.org/10.1080/19420862.2024.2304624

Berteau C, Filipe-Santos O, Wang T, Rojas HE, Granger C, Schwarzenbach F. Evaluation of the impact of viscosity, injection volume, and injection flow rate on subcutaneous injection tolerance. Med Devices (Auckl) 2015; 8: 473–484. DOI: https://doi.org/10.2147/MDER.S91019

van den Bemt BJF, Gettings L, Domańska B, Bruggraber R, Mountian I, Kristensen LE. A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience. Drug Deliv 2019; 26: 384–392. DOI: https://doi.org/10.1080/10717544.2019.1587043

Olsson M, Bajpai R, Wee LWY, Yew YW, Koh MJA, Thng S, et al. The cost of childhood atopic dermatitis in a multi-ethnic Asian population: a cost-of-illness study. Br J Dermatol 2020; 182: 1245–1252. DOI: https://doi.org/10.1111/bjd.18442

Published

2026-08-27

How to Cite

Delesalle, C., Huitric, A., Brenaut, E., Misery, L., & Abasq-Thomas, C. (2026). Injection-related Pain and the Benefit of a Syringe Pump for Dupilumab Adherence in Children with Atopic Dermatitis: a Retrospective Cross-sectional Study. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0553

Issue

Section

Research letter

Categories