Artificial Daylight Photodynamic Therapy with Methyl Aminolevulinate Using an Abbreviated Illumination Protocol with the MultiLite Lamp System in Patients with Actinic Keratoses

Authors

  • Mokone Mengis Faculty of Health, University Witten-Herdecke, Witten, Germany; Hautzentrum Köln (Cologne Dermatology), Cologne, Germany
  • Wolfgang G. Philipp-Dormston Faculty of Health, University Witten-Herdecke, Witten, Germany; Hautzentrum Köln (Cologne Dermatology), Cologne, Germany https://orcid.org/0000-0001-9745-2369

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0611

Keywords:

actinic keratosis, photodynamic therapy

Downloads

Download data is not yet available.

References

Fuchs A, Marmur E. The kinetics of skin cancer: progression of actinic keratosis to squamous cell carcinoma. Dermatol Surg 2007; 33: 1099–1101. DOI: https://doi.org/10.1111/j.1524-4725.2007.33224.x

Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet 1988; 1: 795–797. DOI: https://doi.org/10.1016/S0140-6736(88)91658-3

Heppt MV, Leiter U, Steeb T, Amaral T, Bauer A, Becker JC, et al. S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma - short version, part 1: diagnosis, interventions for actinic keratoses, care structures and quality-of-care indicators. J Dtsch Dermatol Ges 2020; 18: 275–294. DOI: https://doi.org/10.1111/ddg.14048

Mpourazanis G, Konschake W, Vogiatzis R, Papalexis P, Georgakopoulou VE, Ntritsos G, et al. The role and effectiveness of photodynamic therapy on patients with actinic keratosis: a systematic review and meta-analysis. Cureus 2022; 14: e26390. DOI: https://doi.org/10.7759/cureus.26390

Arisi M, Rossi MT, Spiazzi L, Guasco Pisani E, Venturuzzo A, Rovati C, et al. A randomized split-face clinical trial of conventional vs indoor-daylight photodynamic therapy for the treatment of multiple actinic keratosis of the face and scalp and photoaging. J Dermatolog Treat 2022; 33: 2250–2256. DOI: https://doi.org/10.1080/09546634.2021.1944594

O’Gorman SM, Clowry J, Manley M, McCavana J, Gray L, Kavanagh A, et al. Artificial white light vs daylight photodynamic therapy for actinic keratoses: a randomized clinical trial. JAMA Dermatol 2016; 152: 638–644. DOI: https://doi.org/10.1001/jamadermatol.2015.5436

Philipp-Dormston WG, Brückner M, Hoffmann M, Baé M, Fränken J, Großmann B, et al. Artificial daylight photodynamic therapy using methyl aminolaevulinate in a real-world setting in Germany: results from the noninterventional study ArtLight. Br J Dermatol 2025; 192: 510–519. DOI: https://doi.org/10.1093/bjd/ljae437

Karrer S, Szeimies RM, Philipp-Dormston WG, Gerber PA, Prager W, Datz E, et al. Repetitive daylight photodynamic therapy versus cryosurgery for prevention of actinic keratoses in photodamaged facial skin: a prospective, randomized controlled multicentre two-armed study. Acta Derm Venereol 2021; 101: adv00355. DOI: https://doi.org/10.2340/00015555-3717

Antonetti P, Arisi M, Pellegrini C, Artelli GL, Zola A, Bruni M, et al. Indoor daylight photodynamic therapy for actinic keratosis of the scalp: intrapatient comparison study of 1 h versus 2 h exposure time. Dermatol Ther 2026; 16: 1113–1124. DOI: https://doi.org/10.1007/s13555-025-01567-z

Wiegell SR, Skiveren J, Philipsen PA, Wulf HC. Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate. Br J Dermatol 2008; 158: 727–733. DOI: https://doi.org/10.1111/j.1365-2133.2008.08451.x

Szeimïes RM. Pain perception during photodynamic therapy: why is daylight PDT with methyl aminolevulinate almost pain-free? A review on the underlying mechanisms, clinical reflections and resulting opportunities. G Ital Dermatol Venereol 2018; 153: 793–799. DOI: https://doi.org/10.23736/S0392-0488.18.06011-X

Published

2026-08-27

How to Cite

Mengis, M., & Philipp-Dormston, W. G. (2026). Artificial Daylight Photodynamic Therapy with Methyl Aminolevulinate Using an Abbreviated Illumination Protocol with the MultiLite Lamp System in Patients with Actinic Keratoses. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0611

Issue

Section

Short Communication

Categories