Haemophagocytic Lymphohistiocytosis Following Severe Erysipelas with EBV Reactivation

Authors

  • Thilo Gambichler Department of Dermatology, Dortmund Hospital gGmbH, University Witten-Herdecke, Dortmund, Germany; Department of Dermatology, Christian Hospital Unna, Unna, Germany; Department of Dermatology, Ruhr-University Bochum, Bochum, Germany https://orcid.org/0000-0001-7862-3695
  • Josefine Brune Department of Dermatology, Dortmund Hospital gGmbH, University Witten-Herdecke, Dortmund, Germany
  • Laura Susok Department of Dermatology, Dortmund Hospital gGmbH, University Witten-Herdecke, Dortmund, German

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0822

Keywords:

macrophage activation syndrome, cellulitis, Epstein-Barr virus

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References

Khare N, Jinkala SR, Kanungo S. Performance of HScore in reactive hemophagocytic lymphohistiocytosis. Indian J Hematol Blood Transfus 2021; 37: 256–263. DOI: https://doi.org/10.1007/s12288-020-01342-4

Chang CC, Hsiao PJ, Chiu CC, Chen YC, Lin SH, Wu CC, et al. Catastrophic hemophagocytic lymphohistiocytosis in a young man with nephrotic syndrome. Clin Chim Acta 2015; 439: 168–171. DOI: https://doi.org/10.1016/j.cca.2014.10.025

Boggio F, Lora V, Cota C, Pereira A, Müllegger R, Prieto-Torres L, et al. Cutaneous hemophagocytosis: clinicopathologic features of 21 cases. J Am Acad Dermatol 2018; 78: 377–382. DOI: https://doi.org/10.1016/j.jaad.2017.08.041

Kuntz N, Grovas LJ, Tang R, Armanyous Y, Hoerig C, Torno L, et al. Cutaneous manifestations in an infant with hemophagocytic lymphohistiocytosis: case report. J Pediatr Hematol Oncol Nurs 2025; 42: 202–209. DOI: https://doi.org/10.1177/27527530251356970

Hall AD, Salibindla D, Dubocq-Cabrera L, Hunt M, Rotert LM, Johnson RS, et al. Progressive disseminated histoplasmosis with dermatomyositis and macrophage activation syndrome/hemophagocytic lymphohistiocytosis. Am J Trop Med Hyg 2025; 113: 773–780. DOI: https://doi.org/10.4269/ajtmh.24-0802

Baba M, Fenech M, Saeed MU, McCormick A, Jawad M. A rare case of orbital inflammation complicated by hemophagocytic lymphohistiocytosis. Orbit 2024; 43: 751–754. DOI: https://doi.org/10.1080/01676830.2023.2274868

Puing AG, Raghavan SS, Aleshin MA, Ho DY. Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis. Med Mycol Case Rep 2021; 33: 18–20. DOI: https://doi.org/10.1016/j.mmcr.2021.06.002

Tzeng HE, Teng CL, Yang Y, Young JH, Chou G. Occult subcutaneous panniculitis-like T-cell lymphoma with initial presentations of cellulitis-like skin lesion and fulminant hemophagocytosis. J Formos Med Assoc 2007; 106: S55–9. DOI: https://doi.org/10.1016/S0929-6646(09)60354-5

Liu D, Pei X, Zhang X, Xu L, Wang Y, Yan C, et al. Clinical manifestations and outcomes of EBV-related secondary hemophagocytic lymphohistiocytosis. Ann Hematol 2025; 104: 5605–5613. DOI: https://doi.org/10.1007/s00277-025-06677-4

La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, et al. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood 2019; 133: 2465–2477. DOI: https://doi.org/10.1182/blood.2018894618

Published

2026-10-07

How to Cite

Gambichler, T., Brune, J., & Susok, L. (2026). Haemophagocytic Lymphohistiocytosis Following Severe Erysipelas with EBV Reactivation. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0822

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Short Communication

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