Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis

Authors

  • Teresa Ju Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, the University of Miami Miller School of Medicine, Miami, FL, USA
  • Angelina Labib Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, the University of Miami Miller School of Medicine, Miami, FL, USA
  • Leigh Nattkemper Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, the University of Miami Miller School of Medicine, Miami, FL, USA
  • Sarah Engle Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
  • Autum Auxier Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
  • Nathan Hahn Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
  • Sean Sissons Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
  • Jonathan T. Sims Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
  • Zhe Sun Discovery/Development Statistics, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN USA
  • Angela J. Okragly Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
  • Gil Yosipovitch Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, the University of Miami Miller School of Medicine, Miami, FL, USA

DOI:

https://doi.org/10.2340/actadv.v103.4804

Keywords:

inflammation, itch, proteomics, prurigo nodularis, pruritus

Abstract

Abstract is missing (Short communication)

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References

Ingrasci G, Lipman ZM, Hawash AA, Girolomoni G, Yosipovitch G. The pruritogenic role of the type 2 immune response in diseases associated with chronic itch. Exp Dermatol 2021; 30: 1208-1217.

https://doi.org/10.1111/exd.14401 DOI: https://doi.org/10.1111/exd.14401

Mikhaylov D, Del Duca E, Guttman-Yassky E. Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis. Expert Rev Proteomics 2021; 18: 345-361.

https://doi.org/10.1080/14789450.2021.1935247 DOI: https://doi.org/10.1080/14789450.2021.1935247

Engle SM, Chang CY, Ulrich BJ, Satterwhite A, Hayes T, Robling K, et al. Predictive biomarker modeling of pediatric atopic dermatitis severity based on longitudinal serum collection. Clin Exp Immunol 2021; 207: 253-262.

https://doi.org/10.1093/cei/uxab009 DOI: https://doi.org/10.1093/cei/uxab009

Belzberg M, Alphonse MP, Brown I, Williams KA, Khanna R, Ho B, et al. Prurigo nodularis is characterized by systemic and cutaneous T helper 22 immune polarization. J Invest Dermatol 2021; 141: 2208-2218.e14.

https://doi.org/10.1016/j.jid.2021.02.749 DOI: https://doi.org/10.1016/j.jid.2021.02.749

Tsoi LC, Hacini-Rachinel F, Fogel P, Rousseau F, Xing X, Patrick MT, et al., Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab. J Allergy Clin Immunol 2022; 149: 1329-1339.

https://doi.org/10.1016/j.jaci.2021.10.004 DOI: https://doi.org/10.1016/j.jaci.2021.10.004

Miron Y, Miller PE, Hughes C, Indersmitten T, Lerner EA, Cevikbas F. Mechanistic insights into the antipruritic effects of lebrikizumab, an anti-IL-13 mAb. J Allergy Clin Immunol 2022; 150: 690-700.

https://doi.org/10.1016/j.jaci.2022.01.028 DOI: https://doi.org/10.1016/j.jaci.2022.01.028

Han JH, Park J, Kang TB, Lee KH. Regulation of caspase-8 activity at the crossroads of pro-inflammation and anti-inflammation. Int J Mol Sci 2021; 22: 3318.

https://doi.org/10.3390/ijms22073318 DOI: https://doi.org/10.3390/ijms22073318

Williams KA, Huang AH, Belzberg M, Kwatra SG. Prurigo nodularis: pathogenesis and management. J Am Acad Dermatol 2020; 83: 1567-1575.

https://doi.org/10.1016/j.jaad.2020.04.182 DOI: https://doi.org/10.1016/j.jaad.2020.04.182

Brembilla NC, Senra L, Boehncke WH. The IL-17 family of cytokines in psoriasis: IL-17A and beyond. Front Immunol 2018; 9: 1682.

https://doi.org/10.3389/fimmu.2018.01682 DOI: https://doi.org/10.3389/fimmu.2018.01682

Gholibeigian Z, Izad M, Daneshpazhooh M, Mortazavi H, Salehi Z, Behruzifar S, Akhdar, et al. Decreased serum levels of interleukin-17, interleukin-23, TGF-β in pemphigus vulgaris patients, and their association with disease phase. Dermatol Ther 2020; 33: e14071.

https://doi.org/10.1111/dth.14071 DOI: https://doi.org/10.1111/dth.14071

Aşkın Ö, Yücesoy SN, Coşkun E, Engin B, Serdaroğlu S. Evaluation of the level of serum interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata. An Bras Dermatol 2021; 96: 551-557.

https://doi.org/10.1016/j.abd.2021.03.006 DOI: https://doi.org/10.1016/j.abd.2021.03.006

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Published

2023-02-07

How to Cite

Ju, T., Labib, A., Nattkemper, L., Engle, S., Auxier, A., Hahn, N., Sissons, S., Sims, J. T., Sun, Z., Okragly, A. J., & Yosipovitch, G. (2023). Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis. Acta Dermato-Venereologica, 103, adv00861. https://doi.org/10.2340/actadv.v103.4804

Issue

Vol. 103 (2023)

Section

Short Communication

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Copyright (c) 2023 Teresa Ju, Angelina Labib, Leigh Nattkemper, Sarah Engle, Autum Auxier, Nathan Hahn, Sean Sissons, Jonathan T. Sims, Zhe Sun, Angela J. Okragly, Gil Yosipovitch

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