Dermal CD271+ Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process
DOI:
https://doi.org/10.2340/00015555-2624Keywords:
Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192, JapanAbstract
Stem cells have recently been shown to play important roles in wound healing. The aim of this study was to investigate the role of dermal CD271+ cells in wound healing. Full-thickness wounds were produced on the backs of 5-year-old and 24-week-old mice, and time-course of wound closure, CD271+ cell counts, and gene expression levels were compared. Delayed wound healing was observed in 24-week-old mice. The peak of CD271+ cell increase was delayed in 24-week-old mice, and gene expression levels of growth factors in wounded tissue were significantly increased in 5-year-old mice. Dermal CD271+ cells purified by fluorescence-activated cell sorting (FACS) expressed higher growth factors than CD271? cells, suggesting that CD271+ cells play important roles by producing growth factors. This study also investigated dermal CD271+ cells in patients with chronic skin ulcers. Dermal CD271+ cells in patients were significantly reduced compared with in healthy controls. Thus, dermal CD271+ cells are closely associated with wound healing.Downloads
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Copyright (c) 2017 Yohei Iwata, Yuichi Hasebe, Seiji Hasegawa, Satoru Nakata, Akiko Yagami, Kayoko Matsunaga, Kazumitsu Sugiura, Hirohiko Akamatsu
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