Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

Authors

  • Martin Glatz
  • Matthias Buchner
  • Wibke von Bartenwerffer
  • Peter Schmid-Grendelmeier
  • Margitta Worm
  • Jürgen Hedderich
  • Regina Fölster-Holst

DOI:

https://doi.org/10.2340/00015555-1864

Keywords:

Malassezia spp., atopic dermatitis, allergen-specific IgE, SCORAD

Abstract

The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (>100 kU/l) in 79.7% of adults and 46.8% of children. Sensitisation frequencies to allergens, particularly microbial allergens, were up to 10-fold higher in adults compared to children. Severity of atopic dermatitis correlated with elevated total IgE in adults (r=0.549, p<0.001) and children (r=0.344, p=0.005) and with Malassezia spp.-specific IgE in adults (r=0.429, p=0.007). Total IgE is a marker for severe atopic dermatitis in both age groups. Malassezia spp.-specific IgE is an important allergen-specific marker for severity of atopic dermatitis in adults.

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Published

2014-08-19

How to Cite

Glatz, M., Buchner, M., von Bartenwerffer, W., Schmid-Grendelmeier, P., Worm, M., Hedderich, J., & Fölster-Holst, R. (2014). Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults. Acta Dermato-Venereologica, 95(2), 191–196. https://doi.org/10.2340/00015555-1864

Issue

Vol. 95 No. 2 (2015)

Section

Articles

License

Copyright (c) 2014 Martin Glatz, Matthias Buchner, Wibke von Bartenwerffer, Peter Schmid-Grendelmeier, Margitta Worm, Jürgen Hedderich, Regina Fölster-Holst

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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