Identification of a Circulating MicroRNA Profile as a Biomarker of Metastatic Cutaneous Melanoma
DOI:
https://doi.org/10.2340/00015555-2156Abstract
No specific biomarkers for prognostication or evaluation of tumour load in melanoma have been reported to our knowledge. MicroRNAs (miRNAs) are strongly implicated in oncogenesis and tumour progression, and their circulating forms have been studied as potential biomarkers in oncology. The aim of this prospective study was to identify a melanoma-specific profile of plasma miRNAs. A screening phase, using RNA microarray, was conducted on plasma from 14 patients with metastatic melanoma and 5 healthy subjects. Selected miRNAs were analysed by RTqPCR in 2 independent training and validation cohorts including, respectively, 29 and 31 patients and 16 and 43 control subjects. A profile of 2 miRNAs (miR-1246 and miR-185) significantly associated with metastatic melanoma with a sensitivity of 90.5% and a specificity of 89.1% was identified. This plasma miRNA profile may become an accurate non-invasive biomarker for melanoma.Downloads
Downloads
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2015 Virginie Armand-Labit, Nicolas Meyer, Anne Casanova, Henri Bonnabau, Valérie Platzer, Emilie Tournier, Benoît Sansas, Stéphane Verdun, Benoit Thouvenot, Benoit Hilselberger, Andrei Doncescu, Laurence Lamant, Magali Lacroix-Triki, Gilles Favre, Anne Pradines
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
