Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus

Authors

  • Gabriel Costa de Carvalho
  • Rosana Domingues
  • Marcelle Almeida de Sousa Nogueira
  • Anna C. Calvielli Castelo Branco
  • Kelly C. Gomes Manfrere
  • Naiura Vieira Pereira
  • Valéria Aoki
  • Mirian Nacagami Sotto
  • Alberto J. Da Silva Duarte
  • Maria Notomi Sato

DOI:

https://doi.org/10.2340/00015555-2306

Abstract

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 were detected in the skin lesions as well as in the sera of subjects with LP. S100A8 expression induced an increased cytotoxic response by peripheral blood CD8+CD107a+ T cells as well as by NK CD56bright cells in patients with LP. Increased expression of interleukin (IL)-1β, tumour necrosis factor (TNF) and IL-6 in the CD8+ T cells of patients with LP was induced by S100A8, in contrast to the control group that produced IL- 10 and interferon (IFN) type I genes. These data suggest that, in individuals with LP, S100A8 may exert distinct immunomodulatory and cytotoxicity functions.

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Published

2015-12-14

How to Cite

Costa de Carvalho, G., Domingues, R., Almeida de Sousa Nogueira, M., Calvielli Castelo Branco, A. C., Gomes Manfrere, K. C., Vieira Pereira, N., … Notomi Sato, M. (2015). Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus. Acta Dermato-Venereologica, 96(4), 485–489. https://doi.org/10.2340/00015555-2306

Issue

Vol. 96 No. 4 (2016)

Section

Articles

License

Copyright (c) 2015 Gabriel Costa de Carvalho, Rosana Domingues, Marcelle Almeida de Sousa Nogueira, Anna C. Calvielli Castelo Branco, Kelly C. Gomes Manfrere, Naiura Vieira Pereira, Valéria Aoki, Mirian Nacagami Sotto, Alberto J. Da Silva Duarte, Maria Notomi Sato

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