Prolonged Sick Leave Before and After Diagnosis of Generalized Pustular Psoriasis: A Swedish Population-based Register Study
DOI:
https://doi.org/10.2340/actadv.v103.6497Keywords:
Generalised pustular psoriasis, sick leave, healthcare register, population-based, epidemiologyAbstract
The aim of this study was to analyse sick leave in generalized pustular psoriasis, the most severe form of pustular psoriasis. Prolonged sick leave of >14 days was analysed for 502 patients with generalized pustular psoriasis compared with controls with psoriasis vulgaris and matched controls from the general population. Using data from the Swedish National Patient Register, and the Longitudinal integrated database for health insurance and labour market studies, the study estimated the mean number of sick leave days in the year of first diagnosis of generalized pustular psoriasis (index year) and for 2 years before and after the index year. Patients with generalized pustular psoriasis were on sick leave to a larger extent than both control populations for all study years. The number of sick leave days peaked in the index year and then reduced. Compared with the control populations, sick leave in generalized pustular psoriasis was already higher prior to diagnosis, indicating delayed diagnosis and/or a comorbidity burden.
Downloads
References
Kharawala S, Golembesky AK, Bohn RL, Esser D. The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review. Expert Rev Clin Immunol 2020; 16: 239-252.
https://doi.org/10.1080/1744666X.2019.1708193 DOI: https://doi.org/10.1080/1744666X.2019.1708193
Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, et al. Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol 2019; 143: 1021-1026.
https://doi.org/10.1016/j.jaci.2018.06.038 DOI: https://doi.org/10.1016/j.jaci.2018.06.038
Hoegler KM, John AM, Handler MZ, Schwartz RA. Generalized pustular psoriasis: a review and update on treatment. J Eur Acad Dermatol Venereol 2018; 32: 1645-1651.
https://doi.org/10.1111/jdv.14949 DOI: https://doi.org/10.1111/jdv.14949
Augey F, Renaudier P, Nicolas JF. Generalized pustular psoriasis (Zumbusch): a French epidemiological survey. Eur J Dermatol 2006; 16: 669-673.
Fabbri P. Psoriasis. From clinical diagnosis to new therapies. Florence, Italy: SEE-Firenze; 2004. (ISBN:978L000002112).
Lee JY, Kang S, Park JS, Jo SJ. Prevalence of psoriasis in Korea: a population based epidemiological study using the Korean National Health Insurance Database. Ann Dermatol 2017; 29: 761-767.
https://doi.org/10.5021/ad.2017.29.6.761 DOI: https://doi.org/10.5021/ad.2017.29.6.761
Löfvendahl S, Norlin JM, Schmitt-Egenolf M. Prevalence and incidence of generalised pustular psoriasis in Sweden - a population-based register study. Br J Dermatol 2022; 186: 970-976.
https://doi.org/10.1111/bjd.20966 DOI: https://doi.org/10.1111/bjd.20966
Ohkawara A, Yasuda H, Kobayashi H, Inaba Y, Ogawa H, Hashimoto I, et al. Generalized pustular psoriasis in Japan: two distinct groups formed by differences in symptoms and genetic background. Acta Derm Venereol 1996; 76: 68-71.
https://doi.org/10.2340/00015555766871 DOI: https://doi.org/10.2340/00015555766871
Zheng M, Jullien D, Eyerich K. The prevalence and disease characteristics of generalized pustular psoriasis. Am J Clin Dermatol 2022; 23: 5-12.
https://doi.org/10.1007/s40257-021-00664-x DOI: https://doi.org/10.1007/s40257-021-00664-x
Hanna ML, Singer D, Valdecantos WC. Economic burden of generalized pustular psoriasis and palmoplantar pustulosis in the United States. Curr Med Res Opin 2021; 37: 735-742.
https://doi.org/10.1080/03007995.2021.1894108 DOI: https://doi.org/10.1080/03007995.2021.1894108
Löfvendahl S, Norlin JM, Schmitt-Egenolf M. Economic burden of generalized pustular psoriasis in Sweden: a population-based register study. Psoriasis 2022; 12: 89-98.
https://doi.org/10.2147/PTT.S359011 DOI: https://doi.org/10.2147/PTT.S359011
Morita A, Kotowsky N, Gao R, Shimizu R, Okubo Y. Patient characteristics and burden of disease in Japanese patients with generalized pustular psoriasis: results from the Medical Data Vision claims database. J Dermatol 2021; 48: 1463-1473.
https://doi.org/10.1111/1346-8138.16022 DOI: https://doi.org/10.1111/1346-8138.16022
Ludvigsson JF, Andersson E, Ekbom A, Feychting M, Kim JL, Reuterwall C, et al. External review and validation of the Swedish national inpatient register. BMC Public Health 2011; 11: 450.
https://doi.org/10.1186/1471-2458-11-450 DOI: https://doi.org/10.1186/1471-2458-11-450
Ludvigsson JF, Almqvist C, Bonamy AK, Ljung R, Michaëlsson K, Neovius M, et al. Registers of the Swedish total population and their use in medical research. Eur J Epidemiol 2016; 31: 125-136.
https://doi.org/10.1007/s10654-016-0117-y DOI: https://doi.org/10.1007/s10654-016-0117-y
Reisner DV, Johnsson FD, Kotowsky N, Brunette S, Valdecantos W, Eyerich K. Impact of generalized pustular psoriasis from the perspective of people living with the condition: results of an online survey. Am J Clin Dermatol 2022; 23: 65-71.
https://doi.org/10.1007/s40257-021-00663-y DOI: https://doi.org/10.1007/s40257-021-00663-y
Strober B, Leman J, Mockenhaupt M, Nakano de Melo J, Nassar A, Prajapati VH, et al. unmet educational needs and clinical practice gaps in the management of generalized pustular psoriasis: global perspectives from the front line. Dermatol Ther (Heidelb) 2022; 12: 381-393.
https://doi.org/10.1007/s13555-021-00661-2 DOI: https://doi.org/10.1007/s13555-021-00661-2
Choon SE, Lai NM, Mohammad NA, Nanu NM, Tey KE, Chew SF. Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis: analysis of 102 cases seen in a tertiary hospital in Johor, Malaysia. Int J Dermatol 2014; 53: 676-684.
https://doi.org/10.1111/ijd.12070 DOI: https://doi.org/10.1111/ijd.12070
Jin H, Cho HH, Kim WJ, Mun JH, Song M, Kim HS, et al. Clinical features and course of generalized pustular psoriasis in Korea. J Dermatol 2015; 42: 674-678.
https://doi.org/10.1111/1346-8138.12863 DOI: https://doi.org/10.1111/1346-8138.12863
Löfvendahl S, Norlin JM, Schmitt-Egenolf M. Comorbidities in patients with generalized pustular psoriasis - a nationwide population-based register study. J Am Acad Dermatol 2023; 88: 736-738.
https://doi.org/10.1016/j.jaad.2022.09.049 DOI: https://doi.org/10.1016/j.jaad.2022.09.049
Okubo Y, Kotowsky N, Gao R, Saito K, Morita A. Clinical characteristics and health-care resource utilization in patients with generalized pustular psoriasis using real-world evidence from the Japanese Medical Data Center database. J Dermatol 2021; 48: 1675-1687.
https://doi.org/10.1111/1346-8138.16084 DOI: https://doi.org/10.1111/1346-8138.16084
Umezawa Y, Ozawa A, Kawasima T, Shimizu H, Terui T, Tagami H, et al. Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. Arch Dermatol Res 2003; 295: S43-54.
https://doi.org/10.1007/s00403-002-0371-6 DOI: https://doi.org/10.1007/s00403-002-0371-6
Zheng J, Chen W, Gao Y, Chen F, Yu N, Ding Y, et al. Clinical analysis of generalized pustular psoriasis in Chinese patients: A retrospective study of 110 patients. J Dermatol 2021; 48: 1336-1342.
https://doi.org/10.1111/1346-8138.15958 DOI: https://doi.org/10.1111/1346-8138.15958
Fujita H, Gooderham M, Romiti R. Diagnosis of generalized pustular psoriasis. Am J Clin Dermatol 2022; 23: 31-38.
https://doi.org/10.1007/s40257-021-00652-1 DOI: https://doi.org/10.1007/s40257-021-00652-1
Ly K, Beck KM, Smith MP, Thibodeaux Q, Bhutani T. Diagnosis and screening of patients with generalized pustular psoriasis. Psoriasis (Auckl) 2019; 9: 37-42.
https://doi.org/10.2147/PTT.S181808 DOI: https://doi.org/10.2147/PTT.S181808
Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Koks S, et al. European consensus statement on phenotypes of pustular psoriasis. J Eur Acad Dermatol Venereol 2017; 31: 1792-1799.
https://doi.org/10.1111/jdv.14386 DOI: https://doi.org/10.1111/jdv.14386
Additional Files
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2023 Sofia Löfvendahl, Jenny M. Norlin, Oskar Ericson, Malin Hanno, Marcus Schmitt-Egenolf
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
