Transient Increase in Circulating Basophils and Eosinophils in Dupilumab-associated Conjunctivitis in Patients with Atopic Dermatitis

Authors

  • Michie Katsuta
  • Yozo Ishiuji Department of Dermatology, The Jikei University School of Medicine, 25-8 Nishi-shimbashi 3-chome, Minato-ku, Tokyo 105-8461, Japan
  • Hiroyuki Matsuzaki
  • Ken-ichi Yasuda
  • Budiman Kharma
  • Yoshimasa Nobeyama
  • Takaaki Hayashi
  • Yoshiki Tokura
  • Akihiko Asahina

DOI:

https://doi.org/10.2340/00015555-3842

Keywords:

atopic dermatitis, basophils, eosinophils, dupilumab associated conjunctivitis, dry eye

Abstract

Abstract is missing (Short communication)

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References

Akinlade B, Guttman-Yassky E, de Bruin-Weller M, Simpson EL, Blauvelt A, Cork MJ, et al. Conjunctivitis in dupilumab clinical trials. Br J Dermatol 2019; 181: 459-473.

DOI: https://doi.org/10.1111/bjd.17869

Faiz S, Giovannelli J, Podevin C, Jachiet M, Bouaziz JD, Reguiai Z, et al. Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort. J Am Acad Dermatol 2019; 81: 143-151.

DOI: https://doi.org/10.1016/j.jaad.2019.02.053

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DOI: https://doi.org/10.1136/bjophthalmol-2019-315010

Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, et al. Japanese guidelines for allergic conjunctival diseases 2017. Allergol Int 2017; 66: 220-229.

DOI: https://doi.org/10.1016/j.alit.2016.12.004

Toda I, Shimazaki J, Tsubota K. Dry eye with only decreased tear break-up time is sometimes associated with allergic conjunctivitis. Ophthalmology 1995; 102: 302-309.

DOI: https://doi.org/10.1016/S0161-6420(95)31024-X

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DOI: https://doi.org/10.1016/j.jaad.2013.10.036

Dogru M, Katakami C, Nakagawa N, Tetsumoto K, Yamamoto M. Impression cytology in atopic dermatitis. Ophthalmology 1998; 105: 1478-1484.

DOI: https://doi.org/10.1016/S0161-6420(98)98032-0

Touhouche AT, Cassagne M, Berard E, Giordano-Labadie F, Didier A, Fournie P, et al. Incidence and risk factors for dupilumab associated ocular adverse events: a real-life prospective study. J Eur Acad Dermatol Venereol 2021; 35: 172-179.

DOI: https://doi.org/10.1111/jdv.16724

Bakker DS, Ariens LFM, van Luijk C, van der Schaft J, Thijs JL, Schuttelaar MLA, et al. Goblet cell scarcity and conjunctival inflammation during treatment with dupilumab in patients with atopic dermatitis. Br J Dermatol 2019; 180: 1248-1249.

DOI: https://doi.org/10.1111/bjd.17538

Voorberg AN, den Dunnen WFA, Wijdh RHJ, de Bruin-Weller MS, Schuttelaar MLA. Recurrence of conjunctival goblet cells after discontinuation of dupilumab in a patient with dupilumab-related conjunctivitis. J Eur Acad Dermatol Venereol 2020; 34: e64-e66.

Kessing SV. Mucous gland system of the conjunctiva. A quantitative normal anatomical study. Acta Ophthalmol (Copenh) 1968: Suppl 95: 91+.

Wollenberg A, Beck LA, Blauvelt A, Simpson EL, Chen Z, Chen Q, et al. Laboratory safety of dupilumab in moderate-to-severe atopic dermatitis: results from three phase III trials (LIBERTY AD SOLO 1, LIBERTY AD SOLO 2, LIBERTY AD CHRONOS). Br J Dermatol 2020; 182: 1120-1135.

DOI: https://doi.org/10.1111/bjd.18434

Imai Y, Yasuda K, Nagai M, Kusakabe M, Kubo M, Nakanishi K, et al. IL-33-induced atopic dermatitis-like inflammation in mice is mediated by group 2 innate lymphoid cells in concert with basophils. J Invest Dermatol 2019; 139: 2185-2194.e3.

Published

2021-06-28

How to Cite

Katsuta, M., Ishiuji, Y., Matsuzaki, H., Yasuda, K.- ichi, Kharma, B., Nobeyama, Y., Hayashi, T., Tokura, Y., & Asahina, A. (2021). Transient Increase in Circulating Basophils and Eosinophils in Dupilumab-associated Conjunctivitis in Patients with Atopic Dermatitis. Acta Dermato-Venereologica, 101(6), adv00483. https://doi.org/10.2340/00015555-3842

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