The role of complement in UVB-induced inflammation
DOI:
https://doi.org/10.2340/0001555566386390Abstract
To evaluate the role of the complement system in skin inflammation accompanying leukocyte infiltration induced by UVB irradiation, the response of guinea pigs decomplemented with cobra venom factor was compared with that in saline-treated animals. Complement-depleted animals showed a weaker clinical response in the late phase (12-48 h) of UVB-induced inflammation (p less than 0.05). However, complement activation, detectable as a decrease in CH50 and generation of chemotactic anaphylatoxin, did not occur after in vitro irradiation of guinea pig serum. These results suggest that although the complement system does not play a key role in initiating leukocyte chemotaxis to the UVB-induced inflammatory site, it contributes to the amplification of the late inflammatory reaction.Downloads
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Published
1986-09-01
How to Cite
Torinuki, W., & Tagami, H. (1986). The role of complement in UVB-induced inflammation. Acta Dermato-Venereologica, 66(5), 386–390. https://doi.org/10.2340/0001555566386390
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Copyright (c) 1986 Acta Dermato-VenereologicaAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
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