Dynamic changes in the epidermal OKT6 positive cells at mild irritant reactions in human skin
DOI:
https://doi.org/10.2340/0001555566117120Abstract
In the present study we induced mild irritant contact reactions by using 0.5% sodium lauryl sulphate (SLS) in distilled water or with distilled water in patch tests for 6 or 24 hours. The biopsies were taken at 6, 24, 48 and 96 hours. Light and electron microscopy were used to assess the irritant reactions produced and the monoclonal antibody OKT6 was used for the detection of the LCs. The number of the epidermal OKT6 positive dendritic cells was found to be increased at 48 and 96 hours after the exposure to SLS and at 96 hours in the water patch tests. It is concluded that mild irritant stimuli cause an increase in the LCs (OKT6 positive cells) and thus might influence and modulate the response to subsequent exposures to allergens.Downloads
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Published
1986-03-01
How to Cite
Lindberg, M., & Emtestam, L. (1986). Dynamic changes in the epidermal OKT6 positive cells at mild irritant reactions in human skin. Acta Dermato-Venereologica, 66(2), 117–120. https://doi.org/10.2340/0001555566117120
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Copyright (c) 1986 Acta Dermato-VenereologicaAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
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