The effect of cyclophosphamide on the toxic contact reaction to croton oil in guinea pig
DOI:
https://doi.org/10.2340/0001555565287290Abstract
Cyclophosphamide is a cytostatic agent used clinically and in experimental studies for its immunosuppressant effect. Effects on the afferent and efferent limb of the contact allergic reaction have been shown. The substance has also non-specific, anti-inflammatory effects and these were investigated in this paper by studying the effects of single doses of cyclophosphamide on the toxic contact reaction to croton oil (a non-specific inflammatory reaction) in guinea pig. Counting of the dermal cellular infiltrate showed that mononuclear and granulocyte counts decreased in a dose-dependent fashion after cyclophosphamide administration. Erythema and oedema in the test reactions decreased generally, although at the highest dose a paradoxical increase was seen.Downloads
Download data is not yet available.
Downloads
Published
1985-07-01
How to Cite
Anderson, C., & Groth, O. (1985). The effect of cyclophosphamide on the toxic contact reaction to croton oil in guinea pig. Acta Dermato-Venereologica, 65(4), 287–290. https://doi.org/10.2340/0001555565287290
Issue
Section
Articles
License
Copyright (c) 1985 Acta Dermato-VenereologicaAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
