Studies on photohemolysis with special reference to demethylchlortetracycline
DOI:
https://doi.org/10.2340/0001555564378383Abstract
Hemolysis induced by ultraviolet radiation as well as demethylchloretetracycline (DMCT) phototoxicity have been investigated in a model using human red blood cells. Total hemolysis for UV-B and UV-C was obtained with 8.3 and 1.9 J/cm2 respectively. DMCT was shown to have pronounced hemolytic properties causing 88% hemolysis at 50 micrograms/ml and 72 J/cm2 of UV-A. No increased hemolysis rate was seen in combination with UV-B. Several factors influencing the results were studied such as incubation time, UV-A dose, drug concentration and different methods for hemoglobin detection. Photohemolysis is an accurate tool for demonstrating DMCT phototoxicity.Downloads
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Published
1984-09-01
How to Cite
Bjellerup, M., & Ljunggren, B. (1984). Studies on photohemolysis with special reference to demethylchlortetracycline. Acta Dermato-Venereologica, 64(5), 378–383. https://doi.org/10.2340/0001555564378383
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