Xerosis is Associated with Atopic Dermatitis, Hand Eczema and Contact Sensitization Independent of Filaggrin Gene Mutations

Authors

  • Jacob P. Thyssen
  • Jeanne D. Johansen
  • Claus Zachariae
  • Torkil Menné
  • Allan Linneberg

DOI:

https://doi.org/10.2340/00015555-1539

Keywords:

xerosis, atopic dermatitis, hand eczema, contact sensitization, general population, epidemiology.

Abstract

Atopic dermatitis, hand eczema and contact sensitization are prevalent disorders, and may, in many cases, be secondary to skin barrier abnormality. The aim of this study was to investigate the association between self-reported generalized xerosis, atopic dermatitis, hand eczema and contact sensitization, taking filaggrin gene mutations into account. Questionnaire data were collected from a cross-sectional study performed in a general population in Copenhagen. A total of 3,460 18–69-year-olds were patch-tested and 3,335 were genotyped for the 2282del4 and R501X mutations in the filaggrin gene. Atopic dermatitis and hand eczema were significantly associated with generalized xerosis, whereas contact sensitization (not nickel) showed only a borderline significant association. These results suggest that generalized xerosis may increase the risk of common skin disorders.

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Published

2013-02-14

How to Cite

Thyssen, J. P., Johansen, J. D., Zachariae, C., Menné, T., & Linneberg, A. (2013). Xerosis is Associated with Atopic Dermatitis, Hand Eczema and Contact Sensitization Independent of Filaggrin Gene Mutations. Acta Dermato-Venereologica, 93(4), 406–410. https://doi.org/10.2340/00015555-1539

Issue

Vol. 93 No. 4 (2013)

Section

Articles

License

Copyright (c) 2013 Jacob P. Thyssen, Jeanne D. Johansen, Claus Zachariae, Torkil Menné, Allan Linneberg

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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