Ultrastructural Demonstration of a Relationship between Acquired Cutis Laxa and Monoclonal Gammopathy

Authors

  • Annabel Maruani
  • Brigitte Arbeille
  • Marie-Christine Machet
  • Christelle Barbet
  • Boris Laure
  • Ludovic Martin
  • Laurent Machet

DOI:

https://doi.org/10.2340/00015555-0887

Keywords:

monoclonal gammopathy, cutis laxa, myeloma, elastolysis, electron microscopy.

Abstract

Acquired cutis laxa is an uncommon disorder sometimes associated with monoclonal gammopathy and multiple myeloma, although the mechanism of this link is unclear. We report here a case of a 34-year-old man with generalized acquired cutis laxa and monoclonal light chain disease with renal and neurological involvement. Electron microscopy examination of a skin sample revealed shortened and fragmented elastic fibres in the reticular dermis and normal collagen bundles. Immunogold labelling revealed anti-lambda antibodies closely bound to the microfibrillar component of elastic fibres, thus supporting a causal relationship between monoclonal gammopathy and the changes in skin elasticity.

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Published

2010-05-24

How to Cite

Maruani, A., Arbeille, B., Machet, M.-C., Barbet, C., Laure, B., Martin, L., & Machet, L. (2010). Ultrastructural Demonstration of a Relationship between Acquired Cutis Laxa and Monoclonal Gammopathy. Acta Dermato-Venereologica, 90(4), 406–408. https://doi.org/10.2340/00015555-0887

Issue

Vol. 90 No. 4 (2010)

Section

Articles

License

Creative Commons License

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