Hepatocellular Carcinoma in Variegate Porphyria: A Serious Complication
DOI:
https://doi.org/10.2340/00015555-0870Keywords:
porphyria, haem biosynthesis, acute hepatic porphyria, variegate porphyria, hepatocellular carcinoma.Abstract
An 8-year-old boy presented with hydroa vacciniforme with recurrent oral mucosal ulcers and treatment-resistant gingivitis/periodontitis. Symptoms of oral mucosal involvement and gingivitis/periodontitis mirrored the severity of the skin lesions in sun-exposed areas. Although Epstein-Barr virus was negative in the skin lesions, Epstein-Barr virus DNA was detected in the gingival lesions when skin disease activity increased. Human herpes viruses-6 and -7 were also positive in the gingival lesions. Notably, human parvovirus B19 DNA was detected in both skin and gingival lesions. Impairment of systemic immunity was not detected. This report describes a rare case of hydroa vacciniforme with mucosal involvement and periodontal disease accompanied by multiple local virus re-activation.Downloads
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Published
2010-08-18
How to Cite
Schneider-Yin, X., van Tuyll van Serooskerken, A.-M., Went, P., Tyblewski, W., Poblete-Gutiérrez, P., Minder, E. I., & Frank, J. (2010). Hepatocellular Carcinoma in Variegate Porphyria: A Serious Complication. Acta Dermato-Venereologica, 90(5), 512–515. https://doi.org/10.2340/00015555-0870
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