Clinical Associations of the Risk Alleles of HLA-Cw6 and CCHCR1*WWCC in Psoriasis
DOI:
https://doi.org/10.2340/00015555-0184Keywords:
HLA-C antigens, psoriatic arthritis, guttate psoriasis, nail, anti-psoriatic drugs.Abstract
The PSORS1 locus is the consistently replicated genetic risk factor for psoriasis. Clinical associations with the main marker allele of PSORS1, HLA-Cw6, have been addressed in a number of studies, but clinical associations have not been used as a way to distinguish the effects of the neighbouring candidate genes in PSORS1. Our results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. The clinical profiling of a small group of patients (n=34) who were HLA-Cw6- but CCHCR1*WWCC positive suggested that no great differences existed between them and HCR-Cw6- patients. HCR+ genotype (as well as Cw6+ genotype) correlated for the first time positively with female sex and, in contrast with previous studies, negatively with disease severity. Presence of psoriatic arthritis was more pronounced in HCR- psoriasis (as well as in Cw6- psoriasis). Clinical profiling may be a useful approach to distinguishing genetic effects of candidate genes even within a locus in sufficiently large cohorts.Downloads
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Published
2007-01-16
How to Cite
Suomela, S., Kainu, K., Onkamo, P., Tiala, I., Himberg, J., Koskinen, L., Snellman, E., Karvonen, S.-L., Karvonen, J., Uurasmaa, T., Reunala, T., Kivikäs, K., Jansén, C. T., Holopainen, P., Elomaa, O., Kere, J., & Saarialho-Kere, U. (2007). Clinical Associations of the Risk Alleles of HLA-Cw6 and CCHCR1*WWCC in Psoriasis. Acta Dermato-Venereologica, 87(2), 127–134. https://doi.org/10.2340/00015555-0184
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