Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species

Authors

  • Helen Priscila Rodrigues Martins
  • Mariana Clivati da Silva
  • Luciene Cássia Farias Paiva
  • Terezinha Inez Estivalet Svidzinski
  • Marcia Edilaine Lopes Consolaro

DOI:

https://doi.org/10.2340/00015555-1194

Keywords:

efficacy, fluconazole, nystatin, treatment, vaginal Candida spp.

Abstract

The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, 27.0% C. glabrata, 13.5% C. tropicalis and 6.3% C. parapsilosis. Treatment was carried out with both drugs. The overall mean cure rates with fluconazole (87.0%) and nystatin (74.0%) were similar; among women with non-albicans, the cure rate with fluconazole was 100%, whereas that with nystatin was 44.4%. The cure rate for women with C. albicans was high with both fluconazole and nystatin; however, for those with non-albicans species the cure rate was excellent with fluconazole and very low with nystatin, differing from the majority of in vitro studies.

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Published

2011-08-17

How to Cite

Priscila Rodrigues Martins, H., Clivati da Silva, M., Cássia Farias Paiva, L., Inez Estivalet Svidzinski, T., & Edilaine Lopes Consolaro, M. (2011). Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species. Acta Dermato-Venereologica, 92(1), 78–82. https://doi.org/10.2340/00015555-1194

Issue

Vol. 92 No. 1 (2012)

Section

Articles

License

Copyright (c) 2011 Helen Priscila Rodrigues Martins, Mariana Clivati da Silva, Luciene Cássia Farias Paiva, Terezinha Inez Estivalet Svidzinski, Marcia Edilaine Lopes Consolaro

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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