Limited Influence of Aspirin Intake on Mast Cell Activation in Patients with Food-dependent Exercise-induced Anaphylaxis: Comparison Using Skin Prick and Histamine Release Tests

Authors

  • Atsushi Fukunaga
  • Hideki Shimizu
  • Mami Tanaka
  • Ayuko Kikuzawa
  • Mariko Tsujimoto
  • Akiko Sekimukai
  • Junji Yamashita
  • Tatsuya Horikawa
  • Chikako Nishigori

DOI:

https://doi.org/10.2340/00015555-1210

Keywords:

food-dependent exercise-induced anaphylaxis, aspirin, histamine release test, skin test, mast cells, basophils.

Abstract

Food-dependent exercise-induced anaphylaxis (FDEIA) is a severe systemic syndrome induced by physical exercise after ingesting causative food. Aspirin is a well-known trigger for anaphylaxis in patients with FDEIA. Possible mechanisms by which symptoms are aggravated by aspirin include enhanced antigen absorption and mast cell activation. The aim of this study was to determine whether aspirin intake has an influence on mast cell/basophil activation in patients with FDEIA. Provocation tests revealed that adding aspirin to the causative food challenge in 7 of 9 (77.8%) patients with FDEIA provoked symptoms. In most cases, pretreatment with aspirin did not enhance skin tests (71.4%) or histamine release tests (88.9%) with food allergen challenges. The study confirmes that histamine release and skin prick tests can be adjunctive tools for diagnosing FDEIA. In addition, our results suggest that exacerbation of FDEIA symptoms by aspirin is not mediated by direct effects of aspirin on mast cell/basophil activation.

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Published

2011-10-25

How to Cite

Fukunaga, A., Shimizu, H., Tanaka, M., Kikuzawa, A., Tsujimoto, M., Sekimukai, A., … Nishigori, C. (2011). Limited Influence of Aspirin Intake on Mast Cell Activation in Patients with Food-dependent Exercise-induced Anaphylaxis: Comparison Using Skin Prick and Histamine Release Tests. Acta Dermato-Venereologica, 92(5), 480–483. https://doi.org/10.2340/00015555-1210

Issue

Vol. 92 No. 5 (2012)

Section

Articles

License

Copyright (c) 2011 Atsushi Fukunaga, Hideki Shimizu, Mami Tanaka, Ayuko Kikuzawa, Mariko Tsujimoto, Akiko Sekimukai, Junji Yamashita, Tatsuya Horikawa, Chikako Nishigori

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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