Immunological and Clinical Effects of Alphacalcidol in Patients with Psoriatic Arthropathy: Results of an Open, Follow-up Pilot Study

Authors

  • János Gaál
  • Gabriella Lakos
  • Péter Szodoray
  • Judit Kiss
  • Irén Horváth
  • Edit Horkay
  • Georgina Nagy
  • Andrea Szegedi

DOI:

https://doi.org/10.2340/00015555-0555

Keywords:

alphacalcidol treatment, psoriatic arthropathy, immunomodulatory effect.

Abstract

The aim of this study was to describe the effect of systemic alphacalcidol (1 OH vitamin D3) treatment on clinical and immunological parameters in patients with psoriatic arthropathy. Among the 19 patients investigated, 10 were treated with 0.25 microg oral alphacalcidol twice daily for 6 months, while 9 other patients served as controls. In the peripheral blood of the treated group but not in the controls, a statistically significant decrease was observed in the percentage of CD3/CD69-positive activated and CD8-positive interferon-gamma-producing T cells and in the serum level of interferon-gamma during the first 3 months and also in the clinical activity of the disease during the whole 6-month follow-up period. Our results show that systemic alphacalcidol treatment has an immunomodulatory effect on patients with psoriatic arthropathy. This effect is manifested by a short-term temporary decrease in type 1 immune responses and a continuous decrease in disease activity.

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Published

2009-02-02

How to Cite

Gaál, J., Lakos, G., Szodoray, P., Kiss, J., Horváth, I., Horkay, E., … Szegedi, A. (2009). Immunological and Clinical Effects of Alphacalcidol in Patients with Psoriatic Arthropathy: Results of an Open, Follow-up Pilot Study. Acta Dermato-Venereologica, 89(2), 140–144. https://doi.org/10.2340/00015555-0555

Issue

Section

Articles