Association between oestrogen receptors and female temporomandibular disorders

Authors

  • Erika Calvano Küchler Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil
  • Michelle Nascimento Meger Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil
  • Marjorie Ayumi Omori Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil
  • Jennifer Tsi Gerber Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil
  • Evandro Carneiro Martins Neto Department of Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil
  • Nilza Cristina da Silva Machado Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil
  • Rafael Corrêa Cavalcante Department of Pediatric Dentistry, Universidade Federal Do Paraná, Curitiba, Brazil
  • Lucas Ribeiro Teixeira Department of Oral Biology, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil
  • Maria Bernadete Stuani Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil
  • Paulo Nelson Filho Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil
  • Delson João da Costa Department of Oral and Maxillofacial Surgery, Universidade Federal Do Paraná, Curitiba, Brazil
  • Juliana Feltrin de Souza Department of Pediatric Dentistry, Universidade Federal Do Paraná, Curitiba, Brazil
  • João Armando Brancher Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil
  • Jorge Esquiche León Department of Oral Pathology, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil
  • Rafaela Scariot Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil; Department of Oral and Maxillofacial Surgery, Universidade Federal Do Paraná, Curitiba, Brazil

DOI:

https://doi.org/10.1080/00016357.2019.1675904

Keywords:

Adolescents, oestrogen receptor modulators, TMJ, TMJ diseases, women

Abstract

Objective: To evaluate if temporomandibular disorders (TMDs) are associated with genetic polymorphisms in ESR1 and ESR2, which are genes encoding oestrogen receptor alpha (ERα) and beta (ERβ). Also, we included an animal model to check if ERα and ERβ are expressed in the temporomandibular joint (TMJ) during adolescence.

Materials and methods: A total of 139 teenagers and 93 adults were diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMDs). The DNA was collected and the markers ESR1 and ERS2 were genotyped. Additionally, immunohistochemistry was performed in TMJ tissues from female Wistar rats during puberty. All data were submitted to statistical analysis with confidence interval of 95%.

Results: Teenagers presented more disc displacement and arthralgia than adults (p < .05). The genetic polymorphism rs1256049 in ESR2 was associated with disc displacement (p = .040; OR = 10.50/95%CI 1.17–98.74) and arthralgia (p = .036; OR = 7.20/95%CI 1.10–46.88) in adults. The ERα and ERβ are expressed in rat TMJ tissues.

Conclusions: We provide evidence that ESR2 is associated with TMD and could be a genetic marker for this condition in adult women. Furthermore, oestrogens receptors are presented in TMJ of adolescent female rats.

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Additional Files

Published

2020-04-02

Issue

Vol. 78 No. 3 (2020): Acta Odontologica Scandinavica

Section

Articles