Oral manifestations of allograft recipients immediately before and after kidney transplantation

Authors

  • Dmitry José de Santana Sarmento Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
  • Rosana Saint Clair Correia Aires Antunes Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
  • Marina Cristelli Division of Renal Transplant, Kidney and Hypertension Hospital, Federal University of São Paulo, São Paulo, Brazil
  • Paulo Henrique Braz-Silva Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil; Division of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil
  • Rafael Maciel Division of Renal Transplant, Social Institute of Health Care, Campina Grande, Brazil
  • José Osmar Medina de Abreu Pestana Division of Renal Transplant, Kidney and Hypertension Hospital, Federal University of São Paulo, São Paulo, Brazil
  • Marina Gallottini Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil

DOI:

https://doi.org/10.1080/00016357.2019.1685680

Keywords:

Kidney transplantation, oral lesions, immunosuppressive agents, candidiasis, stomatitis

Abstract

Objective: To identify the oral lesions of individuals with kidney disease immediately before and shortly after kidney transplantation, taking into account the immunosuppressive regimen, antiviral prophylaxis and type of transplantation.

Methods: A prospective observational cohort study was carried from January 2017 to January 2018. Eighty individuals aged 18 years or older who were admitted for kidney transplantation were eligible to participate. Clinical data regarding medical history, immunosuppressive therapy, antiviral prophylaxis, laboratorial data and oral examination were performed by the same trained researcher, in three different moments: 24 hours before transplantation (1st time point), 15–20 days (2nd time point) and 45–60 days (3rd time point) after transplantation.

Results: In the first, second and third time points, it was found that 3.7% (3/80), 23.7% (18/76) and 25.7% (19/74) of the participants showed oral soft tissue lesions. Ulcers and candidiasis were the most frequent oral lesions, and they were associated with the use of everolimus (p = .005) and azathioprine (p = .034), respectively. Less patients reported xerostomia after transplantation than before (p < .001).

Conclusions: Oral lesions are common in the short term after renal transplantation and are particularly related to both toxicities of immunosuppressive drugs and immunosuppression.

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Published

2020-04-02

Issue

Vol. 78 No. 3 (2020): Acta Odontologica Scandinavica

Section

Articles