Vitamin D deficiency is a risk factor for delayed tooth eruption associated with persistent primary tooth

Authors

  • Thaís Aparecida Xavier a Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil; b Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo – Avenida do Café, São Paulo, Brazil
  • Isabela Ribeiro Madalena a Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Raquel Assed Bezerra da Silva a Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Léa Assed Bezerra da Silva a Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Marcelo José Barbosa Silva c Laboratory of Tumor Biomarkers and Osteoimmunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil
  • Andiara De Rossi a Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Erika Calvano Küchler a Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Sandra Yasuyo Fukada b Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo – Avenida do Café, São Paulo, Brazil

DOI:

https://doi.org/10.1080/00016357.2021.1918762

Keywords:

25-Hydroxyvitamin D, vitamin D deficiency, tooth eruption, single nucleotide polymorphism

Abstract

Objective

To verify the association between 25(OH)D level and polymorphisms in the vitamin D receptor gene (VDR) with the disturbance in the dental development and eruption.

Design

A total of 183 children from two datasets were evaluated. The first dataset was a case–control (15:15) designed to assess if persistent primary tooth (PPT) is associate with serum 25(OH)D level and with genetic polymorphisms in VDR. The second dataset of genomic DNA samples from 54 children with delayed tooth eruption (DTE) and 99 controls were analysed to verify if genetic polymorphisms in VDR (rs2228570 and rs739837) are associated with DTE. The 25(OH)D and the genotyping/allele distribution were analysed using the T-test and chi-square test, respectively.

Results

The level of 25(OH)D in the PPT group (24.9 ± 6.4 mg/mL) was significantly lower than the control (30.0 ± 7.0 mg/mL) (p=.047). Our data show that children with 25(OH)D deficiency are more likely to present PPT (OR = 2.36; 95%CI: 1.51, 3.70). The rs739837 and rs2228570 polymorphisms were not associated with DTE (OR = 1.44; 95%CI: 0.87, 2.39 and OR = 0.80; 95%CI: 0.45, 1.44, respectively).

Conclusions

Vitamin D deficiency is a risk factor for PPT.

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Published

2021-11-17

Issue

Vol. 79 No. 8 (2021): Acta Odontologica Scandinavica

Section

Articles