Denture Stomatitis IV. An Experimental Model in Monkeys

Abstract

An experimental candida infection of the palatal mucosa of 6 Macaca irus was produced by inoculation of C. albicans under an acrylic plate. A diffuse erythema was seen involving the palatal mucosa in contact with the acrylic plate. Infection appeared to be associated with a transformation of the yeast form of C. albicans into the hyphal form. However, histological sections did not show intra-epithelial invasion by hyphae. The inflammatory lesion showed spontaneous healing 2-3 weeks after infection, clinically and histologically. Prolonged topical treatment with Demethylchlortetracycline resulted in a continuous proliferation of candida and a sustained inflammatory reaction, more intense than that caused by candida alone. After re-infection a more intense inflammation appeared as compared with the primary lesion, a fact that may indicate that the experimental candida infection is capable of stimulating delayed hypersensitive responses.