Lactate dehydrogenase (LDH) isoenzyme pattern in normal and inflamed human dental pulp

Authors

  • Edward Berger Messelt Department of Anatomy, Dental Faculty, University of Oslo, Blindern, Oslo, Norway
  • Ole Skogedal Department of Anatomy, Dental Faculty, University of Oslo, Blindern, Oslo, Norway
  • Harald M. Eriksen Department of Anatomy, Dental Faculty, University of Oslo, Blindern, Oslo, Norway

DOI:

https://doi.org/10.3109/00016357809029086

Keywords:

Biochemistry, histochemistry

Abstract

Messelt E. B., Skogedal, O. Erik sen, H.M. Lactate Dehydrogenase (LDH) Isoenzyme pattern in normal and Inflamed Human Dental Pulp.

Enzyme variants may serve an adaptive role in providing the correct vectorial properties for the metabolism of a tissue, or broadening its environmental tolerance range.

To determine if the LDH isoenzyme pattern of human dental pulp changes during inflammation, supernatants from normal and inflamed dental pulp homogenates were separated by polyacrylamide gel elec-trophoresis.

Inflamed pulps had a higher M subunit content and a markedly increased enzyme activity. These results might reflect adaptive changes at the enzyme level associated with a partial shiit towards anaerobic metabolism during inflammation of the pulp.

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Published

1978-01-01

Issue

Vol. 36 No. 5-6 (1978): Acta Odontologica Scandinavica

Section

Articles