Normal Keratinized Mucosa Transplants in Nude Mice

Authors

  • Palle Holmstrup Departments of Oral Pathology, Oral Diagnosis and Oral Surgery, Royal Dental College, Kommunehospitalet, Copenhagen, Denmark; Department of Oral Medicine and Oral Surgery, University Hospital (Rigshospitalet) and Kommunehospitalet, Copenhagen, Denmark; Pathological-anatomical Institute, Kommunehospitalet, Copenhagen, Denmark
  • Erik Dabelsteen Departments of Oral Pathology, Oral Diagnosis and Oral Surgery, Royal Dental College, Kommunehospitalet, Copenhagen, Denmark; Department of Oral Medicine and Oral Surgery, University Hospital (Rigshospitalet) and Kommunehospitalet, Copenhagen, Denmark; Pathological-anatomical Institute, Kommunehospitalet, Copenhagen, Denmark
  • Jesper Reibel Departments of Oral Pathology, Oral Diagnosis and Oral Surgery, Royal Dental College, Kommunehospitalet, Copenhagen, Denmark; Department of Oral Medicine and Oral Surgery, University Hospital (Rigshospitalet) and Kommunehospitalet, Copenhagen, Denmark; Pathological-anatomical Institute, Kommunehospitalet, Copenhagen, Denmark
  • Flemming Harder Departments of Oral Pathology, Oral Diagnosis and Oral Surgery, Royal Dental College, Kommunehospitalet, Copenhagen, Denmark; Department of Oral Medicine and Oral Surgery, University Hospital (Rigshospitalet) and Kommunehospitalet, Copenhagen, Denmark; Pathological-anatomical Institute, Kommunehospitalet, Copenhagen, Denmark

DOI:

https://doi.org/10.3109/00016358109162279

Keywords:

Oral mucosa, histology, epithelial-mesenchymal interaction

Abstract

Abstract

Two types of normal keratinized mucosa were transplanted to subcutaneous sites of nude mice of two different strains. 24 intact specimens of clinically normal human palatal mucosa were transplanted to nude mice of the strain nu/nu NC. The transplants were recovered after 42 d with a recovery rate of 96 %. Moreover, 22 intact specimens of normal rat forestomach mucosa were transplanted to nude mice of the strain nu/nu BALB/c/BOM. These transplants were recovered after 21 d with a recovery rate of 63 %. The histologic features of the transplants were essentially the same as those of the original tissues. However, epithelial outgrowths from the transplants differed with respect to the pattern of keratinization. The outgrowths of human palatal mucosa transplants were essentially unkeratinized, while the outgrowths of the rat forestomach transplants showed continued keratinization.

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Published

1981-01-01

Issue

Vol. 39 No. 4 (1981): Acta Odontologica Scandinavica

Section

Articles