β-lumicolchicine as a Tool to Elucidate Microtubular Function in Dentinogenesis

Authors

  • Jon Einar Dahl Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway
  • Torbjørn Stene Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway
  • Hanna Strømme Koppang Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway
  • Rolf Koppang Department of Dental Technology, Dental Faculty, University of Oslo, Oslo, Norway
  • Torvald Stokke Department of Dental Technology, Dental Faculty, University of Oslo, Oslo, Norway

Keywords:

Colchicine derivatives, incisor, irregular dentin, rat, vinca alkaloids

Abstract

Abstract

β-lumicolchicine, an isomer of colchicine which does not interrupt microtubular function, was given to 8 rats in a dose of 1.5 mg/kg. Four rats served as controls. Histomorphological investigations of odontoblasts and dentin in the maxillary incisors after two weeks revealed no disturbances. This finding, compared with the previously reported effects of colchicine, as well as colcemid, vincristine and vinblastine, indicates dentin production to be dependant on microtubules.

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Published

1981-01-01

Issue

Vol. 39 No. 4 (1981): Acta Odontologica Scandinavica

Section

Articles