Influence of Central Dopaminergic and Oral Sensory Stimulation on the Tone of the Rat Masseter Muscle

Abstract

Dopamine neurons in the nigrostriatal subgroup of the basal ganglia are involved in the higher control of muscle tone and repetitive movements, possibly also in the masticatory muscles. For this reason, the effect of mechanical oral stimulation in combination with apomorphine-induced stimulation of dopamine receptors in the brain was experimentally studied in the rat. The masseter muscle tone during and after anesthesia was registered. A tachograph preamplifier and a bipolar electrode were used for the recording of summated potentials from the muscle. Dopaminergic stimulation increased the muscle tone. Oral sensory stimulation alone showed a tendency to increase the masseter tone, although the increase was not statistically significant. The increase of the tone with dopaminergic stimulation is presumably due to the fact that the dopaminergic system in the basal ganglia also controls the motor function of the masticatory muscles. Several pathological conditions of the mouth region, where a dopaminergic mechanism in the facilitation and inhibition of centrally coordinated jaw reflexes is obvious or possible, are discussed. Individual variation in neuronal dopamine synthesis, uptake, or receptor sensitivity may be one of the factors determining predisposition to masticatory disturbances both in experimental and clinical conditions.