Effects of methylmercury chloride on rat incisor odontoblasts and dentinogenesis

Authors

  • Jon Einar Dahl Department of Pathology, Dental Faculty, University of Oslo, Oslo, Norway

DOI:

https://doi.org/10.3109/00016358408993878

Keywords:

Endoplasmic reticulum, interglobular dentin, mantle dentin, morphology

Abstract

Abstract

Methylmercury chloride, a well-known nerve cell toxicant, was administered to 40 rats in 2 groups, in doses of 10mg/kg and 20mg/kg. Histomorphologic investigation of maxillary incisors after 2 and 4 days revealed granular and hydropic changes in parts of the odontoblastema. Deposition of interglobular dentin was seen after 7 and 11 days. The most vulnerable cells seemed to be the mantle dentin-producing odontoblasts, and the alterations found are probably due to interference with the rough endoplasmic reticulum.

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Published

1984-01-01

Issue

Vol. 42 No. 4 (1984): Acta Odontologica Scandinavica

Section

Articles