Nifedipine regulated periodontal ligament remodeling: An experimental study in rats

Authors

  • Miao-Miao Zhang Department of Orthodontics, College of Stomatology; Department of Pharmacology
  • Dong-Fei Feng Department of Orthodontics, College of Stomatology
  • Ping Shao Department of Orthodontics, College of Stomatology
  • Ting-Ting Sun Department of Orthodontics, College of Stomatology
  • Ling Wang Department of Pharmacology
  • Bao-Feng Yang Department of Pharmacology; Province-State Key Laboratory, Harbin Medical University, Harbin, 150001, PR China

DOI:

https://doi.org/10.1080/00016350802208398

Keywords:

Matrix metalloproteinase, nifedipine, orthodontic tooth movement, periodontal ligament remodeling

Abstract

Objective. The aim of this study was to investigate the effects of nifedipine on periodontal ligament remodeling during orthodontic tooth movement. Material and methods. Sixty male Sprague-Dawley rats were randomly divided into an orthodontic group and groups that received either 10 mg/kg or 40 mg/kg nifedipine (NIF). Immunohistochemical staining and image analysis were used to investigate the expression of matrix metalloproteinase (MMP)-1, -10, -13 and collagen-I in PDL, and maxillary 1st molar displacement was measured. Results. Expression of MMP-1, -10, and -13 was significantly decreased in both NIF groups, while collagen-I expression was markedly increased. NIF significantly inhibited tooth movement. Conclusions. NIF affects the expression of MMP-1, -10, -13 and collagen-I and tooth movement induced by orthodontic force in rats, thus indicating that calcium channels might be important in mediating PDL remodeling.

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Published

2008-01-01

Issue

Vol. 66 No. 6 (2008): Acta Odontologica Scandinavica

Section

Articles