Immediate and delayed effects of repeated doxorubicin injections on rat incisor mesenchymal cells
DOI:
https://doi.org/10.3109/00016358509064146Abstract
Effects of multiple injections of the cytotoxic drug doxorubicin hydrochloride (Adriamycina) on incisor mesenchymal cells were studied by light microscopy. Rats were killed 1 day after two and three injections, and 1 day and 5 days after four injections. Doses of 5 and 10 mg/kg were used and given on consecutive days. Necrotic alterations expanded in preodontoblast and basal pulp regions when the total dose was increased and finally embraced the entire progenitive part of the incisor. The necrotic area became encapsulated by cellular predentin produced by differentiated pulp cells to prevent further tissue damage, and commencing regeneration was observed after 5 days. When the total dose was split up, the cytotoxicity of doxorubicin increased.
Acta Odontologica Scandinavica publishes original research papers as well as critical reviews relevant to the diagnosis, epidemiology, health service, prevention, aetiology, pathogenesis, pathology, physiology, microbiology, development and treatment of diseases affecting tissues of the oral cavity and associated structures including papers on cause and effect or explanatory/associative relationships for experimental or observational studies.
