Effects of mercuric ions on isolated guinea-pig ileum
DOI:
https://doi.org/10.3109/00016358608997722Abstract
AbstractThe possible physiological significance of low concentrations of Hg2+ in the guinea-pig ileum has been investigated. Responses to nerve stimulation by single electrical shocks, acetylcholine (ACh), and histamine (Hi) and the response to ACh of a depolarized preparation were examined. A stimulant effect of Hg2+, in the concentration range of 10 nM-1 üM, dominated in intestine accommodated in biological saline solution. This excitatory effect was probably mainly due to stimulation of a depolarization-coupled initiation of the contraction. The inhibitory effect of Hg2+, 10 nM-1 üM, observed in depolarized muscle was presumably due to a decreased Ca2+ availability for the contractile process. In the higher concentration range, 1-100 üM, a probably direct action on the contractile elements causing irreversible deterioration of the preparation seems to be present. ▪Amalgams; cholinergic transmission; corrosion; excitable tissue; smooth muscle
Acta Odontologica Scandinavica publishes original research papers as well as critical reviews relevant to the diagnosis, epidemiology, health service, prevention, aetiology, pathogenesis, pathology, physiology, microbiology, development and treatment of diseases affecting tissues of the oral cavity and associated structures including papers on cause and effect or explanatory/associative relationships for experimental or observational studies.
