Induction of oral cancer by 7,12-dimethylbenz-[a] anthracene in rats with liver cirrhosis

Authors

  • Ulf Lekholm The Brånemark Clinic, Public Dental Health Service of Gothenburg, Department of Oral Pathology, Faculty of Odontology, University of Gothenburg, Gothenburg, Sweden
  • GÖRan Stenman The Brånemark Clinic, Public Dental Health Service of Gothenburg, Department of Oral Pathology, Faculty of Odontology, University of Gothenburg, Gothenburg, Sweden

DOI:

https://doi.org/10.3109/00016358909007711

Keywords:

Experimental study, lipid-soluble carcinogen, oral carcinogenesis, squamous cell carcinoma, xerostomia

Abstract

Abstract

The effects of carbon tetrachloride-induced liver cirrhosis and xerostomia on oral carcinogenesis were studied in rats given the lipid-soluble carcinogen 7,12-dimethylbenz-[a]anthracene (DMBA). The first carcinoma was detected after only 1 month of DMBA applications. After a further 8 months 85% of the animals had developed one or more squamous cell carcinomas. The latency period for DMBA-induced oral cancer in cirrhotic rats with xerostomia was markedly reduced in comparison with previous findings from xerostomic rats without liver cirrhosis. The results support earlier epidemiologic studies indicating a relationship between liver cirrhosis and oral cancer.

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Published

1989-01-01

Issue

Vol. 47 No. 5 (1989): Acta Odontologica Scandinavica

Section

Articles