Influence of age and immunization on development of gingivitis in rats

Authors

  • Predrag Lekic Departments of Oral Diagnosis, Microbiology, Periodontology, and Pedodontics, Royal Dental College, Bartholin Institute, Kommunehospitalet, Denmark; Department of Pathology, Hvidovre Hospital, Copenhagen, Denmark; Clinic for Pedodontics and Preventive Dentistry, Faculty of Stomatology, University of Belgrade, Belgrade, Yugoslavia
  • Bjarne Klausen Departments of Oral Diagnosis, Microbiology, Periodontology, and Pedodontics, Royal Dental College, Bartholin Institute, Kommunehospitalet, Denmark; Department of Pathology, Hvidovre Hospital, Copenhagen, Denmark; Clinic for Pedodontics and Preventive Dentistry, Faculty of Stomatology, University of Belgrade, Belgrade, Yugoslavia
  • Erik Friis-hasché Departments of Oral Diagnosis, Microbiology, Periodontology, and Pedodontics, Royal Dental College, Bartholin Institute, Kommunehospitalet, Denmark; Department of Pathology, Hvidovre Hospital, Copenhagen, Denmark; Clinic for Pedodontics and Preventive Dentistry, Faculty of Stomatology, University of Belgrade, Belgrade, Yugoslavia
  • Dragan Beloica Departments of Oral Diagnosis, Microbiology, Periodontology, and Pedodontics, Royal Dental College, Bartholin Institute, Kommunehospitalet, Denmark; Department of Pathology, Hvidovre Hospital, Copenhagen, Denmark; Clinic for Pedodontics and Preventive Dentistry, Faculty of Stomatology, University of Belgrade, Belgrade, Yugoslavia
  • Milijana Knezevic Departments of Oral Diagnosis, Microbiology, Periodontology, and Pedodontics, Royal Dental College, Bartholin Institute, Kommunehospitalet, Denmark; Department of Pathology, Hvidovre Hospital, Copenhagen, Denmark; Clinic for Pedodontics and Preventive Dentistry, Faculty of Stomatology, University of Belgrade, Belgrade, Yugoslavia
  • Hans Petter Hougen Departments of Oral Diagnosis, Microbiology, Periodontology, and Pedodontics, Royal Dental College, Bartholin Institute, Kommunehospitalet, Denmark; Department of Pathology, Hvidovre Hospital, Copenhagen, Denmark; Clinic for Pedodontics and Preventive Dentistry, Faculty of Stomatology, University of Belgrade, Belgrade, Yugoslavia

DOI:

https://doi.org/10.3109/00016358909007707

Keywords:

Animal models, host response, periodontat disease

Abstract

Abstract

To study the effect of age and antigenic priming on the development of gingivitis, 33 healthy rats were placed in contact with Streptococcus mutans, Actinomyces viscosus, Fusobacterium nucleatum, and Bacteroides gingivalis. On days 0, 3, 7, and 14 after inoculation, the gingival condition was judged clinically and histologically, and serum antibody titers against the bacteria were measured. The rats were divided into three groups: 1 month old, 3 months old, and 3 months old immunized. None of the young rats developed gingivitis during the experiment, whereas half of the adult and all of the adult immunized rats bled on probing on days 7 and 14. In general, antibody titers against the bacteria were low in young rats, moderate in adult rats, and high in adult immunized rats. These results indicate that adult rats react stronger to plaque antigens than young rats and that previous contact with the antigens increases the reaction.

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Published

1989-01-01

Issue

Vol. 47 No. 4 (1989): Acta Odontologica Scandinavica

Section

Articles