The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function

Authors

  • Richard S. Blumberg Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Yvonne van de Wal Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Steven Claypool Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Nadia Corazza Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Bonny Dickinson Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Edward Nieuwenhuis Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Richard Pitman Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Gerburg Spiekermann Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Xiaoping Zhu Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Sean Colgan Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Wayne I. Lencer Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, and Department of Cell Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA

DOI:

https://doi.org/10.1080/000163501750266729

Keywords:

Epithelium Intestine Major Histocompatibility Complex

Abstract

The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class-I genes: human leukocyte antigens (HLA) A, B, and C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa β2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed, polymorphic proteins, the human genome also encodes several nonclassical MHC class-I-like, or class Ib, genes that, in general, encode nonpolymorphic molecules involved in various specific immunological functions. Many of these genes, including CD1, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chainrelated gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.

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Published

2001-01-01

Issue

Vol. 59 No. 3 (2001): Acta Odontologica Scandinavica

Section

Articles