Glycosaminoglycans in normal and osteoarthrotic human temporomandibular joint disks

Authors

  • Susanna Axelsson Departments of Clinical Oral Physiology, Oral Surgery, and Pathology, Huddinge University Hospital, Huddinge, Sweden
  • Anders Holmlund Departments of Clinical Oral Physiology, Oral Surgery, and Pathology, Huddinge University Hospital, Huddinge, Sweden
  • Anders Hjerpe Departments of Clinical Oral Physiology, Oral Surgery, and Pathology, Huddinge University Hospital, Huddinge, Sweden

DOI:

https://doi.org/10.3109/00016359209012753

Abstract

Glycosaminoglycans in normal and osteoarthrotic temporomandibular joint disks were studied by means of high-performance liquid chromatography methods. Normal disk tissue contains galactosaminoglycans (chondroitin sulfate and dermatan sulfate) as the main polysaccharides and with smaller amounts of hyaluronate and heparan sulfate. The galactosaminoglycans are mainly sulfated in 6-position, and some of the disaccharides contain iduronic acid. There was a slight general variation in glycosaminoglycan concentration with increasing age. In the severely arthrotic disks the content of glycosaminoglycans was considerably lower than in normal disk tissue. This decrease was far more extensive than that observed in relation to age in normal tissue. The 4/6-sulfate ratio of the galactosaminoglycans was increased, whereas the proportion of iduronic acid was markedly decreased. □ High-performance liquid chromatography; polysaccharides

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Published

1992-01-01

Issue

Vol. 50 No. 2 (1992): Acta Odontologica Scandinavica

Section

Articles