Prostaglandin E2 Level in Gingival Crevicular Fluid from Patients with Down Syndrome
DOI:
https://doi.org/10.3109/00016359709115400Keywords:
Children, gingivitis, interleukin-1β, periodontal diseaseAbstract
Barr-Agholme M, Krehanova L, Yucel-Lindberg T, Shinoda K, Modéer T. Prostaglandin E2 level in gingival crevicular fluid from patients with Down syndrome.
The levels of prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) were determined in gingival crevicular fluid (GCF) collected &om patients with gingivitis: 15 Dog syndrome children and 15 controls. The mean level of PGE2 in GCF was significantly higher (P <0.05) in the Down syndrome group (10.0 pg/μl GCF) than in the control group (4.6 pg/μl GCF). In GCF samples collected from sites characterized as noninflamed, the mean level of PGE2 was significantly higher (P < 0.001) in the Down syndrome group than in the controls. The mean level of PGE2 in samples from inflamed sites, on the other hand, did not differ between the two groups. The mean level of IL-1β was not significantly higher in the Down syndrome group than in the controls. This study shows that the level of PGEl detected in GCF &om Down syndrome patients is increased, a fact that may be of importance in the pathogenesis of the periodontal disease frequently seen in these patients.
Acta Odontologica Scandinavica publishes original research papers as well as critical reviews relevant to the diagnosis, epidemiology, health service, prevention, aetiology, pathogenesis, pathology, physiology, microbiology, development and treatment of diseases affecting tissues of the oral cavity and associated structures including papers on cause and effect or explanatory/associative relationships for experimental or observational studies.
