Peripheral lymphocyte subpopulations in recurrent aphthous ulceration

Authors

  • Anne Pedersen Dental Department, University Hospital (Rigshospitalet), Copenhagen, Denmark; Department of Periodontology, Royal Dental College, University Institute of Forensic Medicine, Copenhagen, Denmark; Department of Clinical Immunology, University Hospital (Rigshospitalet), Copenhagen, Denmark
  • Bjarne Klausen Dental Department, University Hospital (Rigshospitalet), Copenhagen, Denmark; Department of Periodontology, Royal Dental College, University Institute of Forensic Medicine, Copenhagen, Denmark; Department of Clinical Immunology, University Hospital (Rigshospitalet), Copenhagen, Denmark
  • Hans Petter Hougen Dental Department, University Hospital (Rigshospitalet), Copenhagen, Denmark; Department of Periodontology, Royal Dental College, University Institute of Forensic Medicine, Copenhagen, Denmark; Department of Clinical Immunology, University Hospital (Rigshospitalet), Copenhagen, Denmark
  • Lars P. Ryder Dental Department, University Hospital (Rigshospitalet), Copenhagen, Denmark; Department of Periodontology, Royal Dental College, University Institute of Forensic Medicine, Copenhagen, Denmark; Department of Clinical Immunology, University Hospital (Rigshospitalet), Copenhagen, Denmark

DOI:

https://doi.org/10.3109/00016359109005908

Keywords:

Aphthae, natural killer cells, oral disease, oral medicine, stomatitis, T lymphocytes

Abstract

Abstract

Peripheral lymphocyte subsets—T-helper (CD4+), T-suppressor/cytotoxic (CD8+), and naive/virgin T cells/natural killer cells (CD45RA)—were studied quantitatively in 30 patients with recurrent aphthous ulceration (RAU) and 29 sex- and age-matched RAU-free control donors. The CD4+ percentage was significantly lower in the patients than in the control group (P < 0.0001), whereas CD8+ and CD4/CD8 ratio figures did not differ significantly between patients and controls. The CD45RA+ counts were significantly higher in the patient group (p < 0.01). The study supports previous investigations with regard to the demonstration of immunologic disturbances in RAU patients. Whether the imbalance is primary or secondary with regard to the basic etiology remains to be resolved.

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Published

1991-01-01

Issue

Vol. 49 No. 4 (1991): Acta Odontologica Scandinavica

Section

Articles