Craniomandibular dysfunction in children treated with total-body irradiation and bone marrow transplantation

Authors

  • Göran Dahllöf Departments of Orthodontics and Pediatric Dentistry and Clinical Oral Physiology, School of Dentistry, Stockholm, Sweden; Departments of Pediatrics, Clinical Immunology, and Transplantation Surgery, Huddinge University Hospital Karolinska Institutet, Stockholm, Sweden
  • Larisa Krekmanova Departments of Orthodontics and Pediatric Dentistry and Clinical Oral Physiology, School of Dentistry, Stockholm, Sweden; Departments of Pediatrics, Clinical Immunology, and Transplantation Surgery, Huddinge University Hospital Karolinska Institutet, Stockholm, Sweden
  • Sigvard Kopp Departments of Orthodontics and Pediatric Dentistry and Clinical Oral Physiology, School of Dentistry, Stockholm, Sweden; Departments of Pediatrics, Clinical Immunology, and Transplantation Surgery, Huddinge University Hospital Karolinska Institutet, Stockholm, Sweden
  • Birgit Borgström Departments of Orthodontics and Pediatric Dentistry and Clinical Oral Physiology, School of Dentistry, Stockholm, Sweden; Departments of Pediatrics, Clinical Immunology, and Transplantation Surgery, Huddinge University Hospital Karolinska Institutet, Stockholm, Sweden
  • Carl-Magnus Forsberg Departments of Orthodontics and Pediatric Dentistry and Clinical Oral Physiology, School of Dentistry, Stockholm, Sweden; Departments of Pediatrics, Clinical Immunology, and Transplantation Surgery, Huddinge University Hospital Karolinska Institutet, Stockholm, Sweden
  • Olle Ringdén Departments of Orthodontics and Pediatric Dentistry and Clinical Oral Physiology, School of Dentistry, Stockholm, Sweden; Departments of Pediatrics, Clinical Immunology, and Transplantation Surgery, Huddinge University Hospital Karolinska Institutet, Stockholm, Sweden

DOI:

https://doi.org/10.3109/00016359409029062

Keywords:

Bone marrow transplantation, child, headache, radiotherapy, temporomandibular joint syndrome

Abstract

Dahllöf G, Krekmanova L, Kopp S, Borgstrom B, Forsberg C-M, Ringdén 0. Craniomandibular dysfunction in children treated with total-body irradiation and bone marrow transplantation. Acta Odontol Scand 1994;52:99–105. Oslo. ISSN 0001-6357

The prevalence of pain and dysfunction in the stomatognathic system was studied in a group of 19 long-term survivors after pediatric bone marrow transplantation (BMT), conditioned with total-body irradiation (TBI). Compared with the control group, the children and adolescents in the BMT group had a significantly reduced mouth opening capacity. A reduced translation movement of the condyles was diagnosed in 53% of children treated with TBI, compared with 5% in the control group. Signs of craniomandibular dysfunction were found in 84% of children in the BMT group, compared with 58% in the control group. Both irradiation and chemotherapy induce long-term alterations in connective and muscle tissues resulting in inflammation and eventually fibrosis. These changes in tissue homeostasis and concomitant growth retardation may lead to the observed malocclusion and reduced mobility of the temporomandibular joint, with subsequent muscle pain and headaches, which were found in this study.

Downloads

Download data is not yet available.

Downloads

Published

1994-01-01

Issue

Vol. 52 No. 2 (1994): Acta Odontologica Scandinavica

Section

Articles