Can the interleukin TNF-α be used as a biomarker for pulp necrosis?

Authors

  • Carlos Wesley Lopes Brasil da Silva Department of Preventive and Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University – UNESP, Araçatuba, Brazil
  • Beatriz Melare de Oliveira Department of Preventive and Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University – UNESP, Araçatuba, Brazil
  • Jheinis Stefany Pascuineli Duarte Department of Preventive and Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University – UNESP, Araçatuba, Brazil
  • Thalya Fernanda Hortsh Maltarollo Department of Preventive and Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University – UNESP, Araçatuba, Brazil
  • Henrico Badaoui Strazzi-Sahyon Department of Prosthodontics and Periodontology, Bauru School of Dentistry, University of São Paulo – USP, Bauru, Brazil; Division of Biomaterial and Biomedical Sciences, Department of Oral Rehabilitation and Biosciences, Oregon Health & Science University, OHSU, Portland, OR, USA
  • Gustavo Sivieri-Araújo Department of Preventive and Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University – UNESP, Araçatuba, Brazil

DOI:

https://doi.org/10.2340/aos.v84.43034

Keywords:

Tumor necrosis factor-alpha, biomarkers, dental pulp necrosis

Abstract

N/A

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References

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Zanini M, Meyer E, Simon S. Pulp inflammation diagnosis from clinical to inflammatory mediators: a systematic review. J Endod. 2017;43(7):1033–51. https://doi.org/10.1016/j.joen.2017.02.009 DOI: https://doi.org/10.1016/j.joen.2017.02.009

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Taira TM, Lima V, Prado DS, Silva TA, Issa JPM, da Silva LAB, et al. NLRP12 attenuates inflammatory bone loss in experimental apical periodontitis. J Dent Res. 2019;98(4):476–84. https://doi.org/​10.1177/0022034518820289 DOI: https://doi.org/10.1177/0022034518820289

Agrawal S, Taneja S, Shetty D, Gopikrishna V, Bhalla VK. Evaluating the concentration of MMP-9 and TNF- α in pulpal blood at various stages of pulpal inflammation in diabetics: a cross sectional study. Eur Endod J. 2023;8(4):286–92. https://doi.org/10.14744/eej.2023.41736 DOI: https://doi.org/10.14744/eej.2023.41736

Zhang Y, Lian M, Zhao X, Cao P, Xiao J, Shen S, et al. RICK regulates the odontogenic differentiation of dental pulp stem cells through activation of TNF-α via the ERK and not through NF-κB signaling pathway. Cell Biol Int. 2021;45(3):569–79. https://doi.org/10.1002/cbin.11498 DOI: https://doi.org/10.1002/cbin.11498

Alsamahi S, Milne TM, Hussaini H, Rich AM, Friedlander LT. Type 2 diabetes and the clinically normal pulp: an in vitro study. Int Endod J. 2022;55(6):660–671. https://doi.org/10.1111/iej.13732 DOI: https://doi.org/10.1111/iej.13732

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Published

2025-02-27

Issue

Vol. 84: (2025) Acta Odontologica Scandinavica

Section

Letter to the Editor

License

Copyright (c) 2025 Carlos Wesley Lopes Brasil da Silva, Beatriz Melare de Oliveira, Jheinis Stefany Pascuineli Duarte, Thalya Fernanda Hortsh Maltarollo, Henrico Badaoui Strazzi-Sahyon, Gustavo Sivieri-Araújo

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This work is licensed under a Creative Commons Attribution 4.0 International License.