Assessment of fractal dimension changes in periapical trabecular patterns following single-visit and multi-visit nonsurgical endodontic treatment with different medicaments: a retrospective study
DOI:
https://doi.org/10.2340/aos.v84.45201Keywords:
Dental radiography, Fractal, Root canal medicaments, Retrospective studies, Root canal therapiesAbstract
Objective: This study aimed to compare time-dependent changes in fractal dimension (FD) and periapical index (PAI) values of periapical trabecular bone in the lesion areas following single- and multi-visit end-odontic treatments using different intracanal medicaments.
Material and Methods: Data from 62 mandibular molars treated between March and December 2023 were analyzed and assigned to three groups: Group 1, multi-visit treatment with calcium hydroxide [Ca(OH)₂] (n = 20); Group 2, multi-visit treatment with chlorhexidine (CHX) gel (n = 21); and Group 3, single-visit treat-ment without medicament (n = 21). Follow-up data were collected until December 2024. Three periapical radiographs, baseline, 6-months, and 12 months after treatment, were evaluated. Fractal analysis was per-formed on a region of interest (ROI) near the infected root apex, and periapical healing was also assessed using PAI scores. PAI scores were compared using the Kruskal–Wallis test; FD values and their correlation with PAI were analyzed by two-way analysis of variance (ANOVA) and Spearman’s test. Categorical variables were compared using the chi-square and Fisher–Freeman–Halton tests.
Results: PAI scores significantly decreased in all groups at 6 and 12 months compared with baseline (p < 0.001), with no intergroup differences (p > 0.05). FD values significantly increased over time in all groups (p < 0.001). The magnitude of FD change and gender-related differences were not significant (p > 0.05). No correlation was observed between PAI and FD values (p > 0.05).
Conclusions: Single- and multi-visit endodontic treatments resulted in similar periapical healing out-comes. The type of intracanal medicament did not influence FD or PAI values. Fractal analysis is a valuable, noninvasive tool for assessing periapical bone healing over time.
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References
Shuping GB, Orstavik D, Sigurdsson A, Trope M. Reduction of intracanal bacteria using nickel-titanium rotary instrumentation and various medications. J Endod. 2000;26(12):751–5. https://doi.org/10.1097/00004770-200012000-00022 DOI: https://doi.org/10.1097/00004770-200012000-00022
Siqueira JF, Jr, Lopes HP. Mechanisms of antimicrobial activity of calcium hydroxide: a critical review. Int Endod J. 1999;32(5):361–9. https://doi.org/10.1046/j.1365-2591.1999.00275.x DOI: https://doi.org/10.1046/j.1365-2591.1999.00275.x
Fava LR. Acute apical periodontitis: incidence of post-operative pain using two different root canal dressings. Int Endod J. 1998;31(5):343–7. https://doi.org/10.1046/j.1365-2591.1998.00159.x DOI: https://doi.org/10.1046/j.1365-2591.1998.00005.x
Siqueira JF, Jr, de Uzeda M. Intracanal medicaments: evaluation of the antibacterial effects of chlorhexidine, metronidazole, and calcium hydroxide associated with three vehicles. J Endod. 1997;23(3):167–9. https://doi.org/10.1016/S0099-2399(97)80268-3 DOI: https://doi.org/10.1016/S0099-2399(97)80268-3
Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J. Present status and future directions of intracanal medicaments. Int Endod J. 2022;55(Suppl 3):613–36. https://doi.org/10.1111/iej.13731 DOI: https://doi.org/10.1111/iej.13731
Sathorn C, Parashos P, Messer HH. Effectiveness of single- versus multiple-visit endodontic treatment of teeth with apical periodontitis: a systematic review and meta-analysis. Int Endod J. 2005;38(6):347–55. https://doi.org/10.1111/j.1365-2591.2005.00955.x DOI: https://doi.org/10.1111/j.1365-2591.2005.00955.x
Paredes-Vieyra J, Enriquez FJ. Success rate of single- versus two-visit root canal treatment of teeth with apical periodontitis: a randomized controlled trial. J Endod. 2012;38(9):1164–9. https://doi.org/10.1016/j.joen.2012.05.021 DOI: https://doi.org/10.1016/j.joen.2012.05.021
Penesis VA, Fitzgerald PI, Fayad MI, Wenckus CS, BeGole EA, Johnson BR. Outcome of one-visit and two-visit endodontic treatment of necrotic teeth with apical periodontitis: a randomized controlled trial with one-year evaluation. J Endod. 2008;34(3):251–7. DOI: https://doi.org/10.1016/j.joen.2007.12.015
Karaoğlan F, Miçooğulları Kurt S, Çalışkan MK. Outcome of single‐versus two‐visit root canal retreatment in teeth with periapical lesions: a randomized clinical trial. Int Endod J. 2022;55(8):833–43. https://doi.org/10.1111/iej.13758 DOI: https://doi.org/10.1111/iej.13758
Kaya S, Yavuz I, Uysal I, Akkuş Z. Measuring bone density in healing periapical lesions by using cone beam computed tomography: a clinical investigation. J Endod. 2012;38(1):28–31. https://doi.org/10.1016/j.joen.2011.09.032 DOI: https://doi.org/10.1016/j.joen.2011.09.032
Magat G, Ozcan Sener S. Evaluation of trabecular pattern of mandible using fractal dimension, bone area fraction, and gray scale value: comparison of cone-beam computed tomography and panoramic radiography. Oral Radiol. 2019;35(1):35–42. https://doi.org/10.1007/s11282-018-0316-1 DOI: https://doi.org/10.1007/s11282-018-0316-1
Tarcin B, Gumru B, Iriboz E, Turkaydin DE, Ovecoglu HS. Radiologic assessment of periapical health: comparison of 3 different index sys-tems. J Endod. 2015;41(11):1834–8. https://doi.org/10.1016/j.joen.2015.08.010 DOI: https://doi.org/10.1016/j.joen.2015.08.010
Orstavik D, Kerekes K, Eriksen HM. The periapical index: a scoring system for radiographic assessment of apical periodontitis. Endod Dent Traumatol. 1986;2(1):20–34. https://doi.org/10.1111/j.1600-9657.1986.tb00119.x DOI: https://doi.org/10.1111/j.1600-9657.1986.tb00119.x
Huang CC, Chen JC, Chang YC, Jeng JH, Chen CM. A fractal dimensional approach to successful evaluation of apical healing. Int Endod J. 2013;46(6):523–9. https://doi.org/10.1111/iej.12020 DOI: https://doi.org/10.1111/iej.12020
Chen SK, Oviir T, Lin CH, Leu LJ, Cho BH, Hollender L. Digital imaging analysis with mathematical morphology and fractal dimension for evaluation of periapical lesions following endodontic treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(4):467–72. https://doi.org/10.1016/j.tripleo.2005.05.075 DOI: https://doi.org/10.1016/j.tripleo.2005.05.075
Yu YY, Chen H, Lin CH, Chen CM, Oviir T, Chen SK, et al. Fractal dimension analysis of periapical reactive bone in response to root canal treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(2):283–8. https://doi.org/10.1016/j.tripleo.2008.05.047 DOI: https://doi.org/10.1016/j.tripleo.2008.05.047
Tosun S, Karataslioglu E, Tulgar MM, Derindag G. Retrospective fractal analyses of one-year follow-up data obtained after single-visit nonsurgical endodontic retreatment on periapical radiographs. Clin Oral Investig. 2021;25(11):6465–72. https://doi.org/10.1007/s00784-021-04079-0 DOI: https://doi.org/10.1007/s00784-021-04079-0
White SC, Rudolph DJ. Alterations of the trabecular pattern of the jaws in patients with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(5):628–35. https://doi.org/10.1016/S1079-2104(99)70097-1 DOI: https://doi.org/10.1016/S1079-2104(99)70097-1
Su Y, Wang C, Ye L. Healing rate and post-obturation pain of single- versus multiple-visit endodontic treatment for infected root canals: a systematic review. J Endod. 2011;37(2):125–32. DOI: https://doi.org/10.1016/j.joen.2010.09.005
Waltimo T, Trope M, Haapasalo M, Ørstavik D. Clinical efficacy of treatment procedures in endodontic infection control and one year follow-up of periapical healing. J Endod. 2005;31(12):863–6. https://doi.org/10.1097/01.don.0000164856.27920.85 DOI: https://doi.org/10.1097/01.don.0000164856.27920.85
Mergoni G, Ganim M, Lodi G, Figini L, Gagliani M, Manfredi M. Single versus multiple visits for endodontic treatment of permanent teeth. Cochrane Database Syst Rev. 2022;12(12):Cd005296. https://doi.org/10.1002/14651858.CD005296.pub4 DOI: https://doi.org/10.1002/14651858.CD005296.pub4
Molander A, Warfvinge J, Reit C, Kvist T. Clinical and radiographic evaluation of one- and two-visit endodontic treatment of asymptomatic necrotic teeth with apical periodontitis: a randomized clinical trial. J Endod. 2007;33(10):1145–8. https://doi.org/10.1016/j.joen.2007.07.005 DOI: https://doi.org/10.1016/j.joen.2007.07.005
Vera J, Siqueira JF, Jr., Ricucci D, Loghin S, Fernández N, Flores B, et al. One- versus two-visit endodontic treatment of teeth with apical periodontitis: a histobacteriologic study. J Endod. 2012;38(8):1040–52. https://doi.org/10.1016/j.joen.2012.04.010 DOI: https://doi.org/10.1016/j.joen.2012.04.010
Holland R, Gomes JEF, Cintra LTA, Queiroz Í OA, Estrela C. Factors affecting the periapical healing process of endodontically treated teeth. J Appl Oral Sci. 2017;25(5):465–76. DOI: https://doi.org/10.1590/1678-7757-2016-0464
Eyuboglu TF, Olcay K, Özcan M. A clinical study on single-visit root canal retreatments on consecutive 173 patients: frequency of periapical complications and clinical success rate. Clin Oral Investig. 2017;21(5):1761–8. https://doi.org/10.1007/s00784-016-1957-2 DOI: https://doi.org/10.1007/s00784-016-1957-2
Uğur Aydın Z, Ocak MG, Bayrak S, Göller Bulut D, Orhan K. The effect of type 2 diabetes mellitus on changes in the fractal dimension of periapical lesion in teeth after root canal treatment: a fractal analysis study. Int Endod J. 2021;54(2):181–9. DOI: https://doi.org/10.1111/iej.13409
Pothuaud L, Benhamou CL, Porion P, Lespessailles E, Harba R, Levitz P. Fractal dimension of trabecular bone projection texture is related to three-dimensional microarchitecture. J Bone Miner Res. 2000;15(4):691–9. https://doi.org/10.1359/jbmr.2000.15.4.691 DOI: https://doi.org/10.1359/jbmr.2000.15.4.691
Arsan B, Köse TE, Çene E, Özcan İ. Assessment of the trabecular structure of mandibular condyles in patients with temporomandibular disorders using fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):382–91. DOI: https://doi.org/10.1016/j.oooo.2016.11.005
Zeytinoğlu M, İlhan B, Dündar N, Boyacioğlu H. Fractal analysis for the assessment of trabecular peri-implant alveolar bone using panoram-ic radiographs. Clin Oral Investig. 2015;19(2):519–24. https://doi.org/10.1007/s00784-014-1245-y DOI: https://doi.org/10.1007/s00784-014-1245-y
Uğur Aydın Z, Toptaş O, Göller Bulut D, Akay N, Kara T, Akbulut N. Effects of root-end filling on the fractal dimension of the periapical bone after periapical surgery: retrospective study. Clin Oral Investig. 2019;23(9):3645–51. https://doi.org/10.1007/s00784-019-02967-0 DOI: https://doi.org/10.1007/s00784-019-02967-0
Aktuna Belgin C, Serindere G. Evaluation of trabecular bone changes in patients with periodontitis using fractal analysis: a periapical radi-ography study. J Periodontol. 2020;91(7):933–7. https://doi.org/10.1002/JPER.19-0452 DOI: https://doi.org/10.1002/JPER.19-0452
Hayek E, Aoun G, Bassit R, Nasseh I. Correlating radiographic fractal analysis at implant recipient sites with primary implant stability: an in vivo preliminary study. Cureus. 2020;12(1):e6539. https://doi.org/10.7759/cureus.6539 DOI: https://doi.org/10.7759/cureus.6539
Jolley L, Majumdar S, Kapila S. Technical factors in fractal analysis of periapical radiographs. Dentomaxillofac Radiol. 2006;35(6):393–7. https://doi.org/10.1259/dmfr/30969642 DOI: https://doi.org/10.1259/dmfr/30969642
Shrout MK, Farley BA, Patt SM, Potter BJ, Hildebolt CF, Pilgram TK,
et al. The effect of region of interest variations on morphologic operations data and gray-level values extracted from digitized den-tal radiographs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(5):636–9. https://doi.org/10.1016/S1079-2104(99)70098-3 DOI: https://doi.org/10.1016/S1079-2104(99)70098-3
Amer ME, Heo MS, Brooks SL, Benavides E. Anatomical variations of trabecular bone structure in intraoral radiographs using fractal and particles count analyses. Imaging Sci Dent. 2012;42(1):5–12. https://doi.org/10.5624/isd.2012.42.1.5 DOI: https://doi.org/10.5624/isd.2012.42.1.5
Tosun S, Karataslioglu E, Tulgar MM, Derindag G. Fractal analysis and periapical index evaluation of multivisit nonsurgical endodontic retreatment: a retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022;133(2):245–51. https://doi.org/10.1016/j.oooo.2021.08.016 DOI: https://doi.org/10.1016/j.oooo.2021.08.016
Marquis VL, Dao T, Farzaneh M, Abitbol S, Friedman S. Treatment outcome in endodontics: the Toronto Study. Phase III: initial treatment. J Endod. 2006;32(4):299–306. https://doi.org/10.1016/j.joen.2005.10.050 DOI: https://doi.org/10.1016/j.joen.2005.10.050
Smith CS, Setchell DJ, Harty FJ. Factors influencing the success of conventional root canal therapy – a five-year retrospective study. Int Endod J. 1993;26(6):321–33. https://doi.org/10.1111/j.1365-2591.1993.tb00765.x DOI: https://doi.org/10.1111/j.1365-2591.1993.tb00765.x
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