Comments on ‘Bisphosphonate and statin: adverse effects of co-medication on wound healing in in vitro models of periodontal tissues’

Authors

  • David Szaraz Clinic of Maxillofacial Surgery, University Hospital Brno, Brno, Czechia; Faculty of Medicine, Masaryk University, Brno, Czechia
  • Vojtech Perina Clinic of Maxillofacial Surgery, University Hospital Brno, Brno, Czechia; Faculty of Medicine, Masaryk University, Brno, Czechia
  • Petra Borilova Linhartova Clinic of Maxillofacial Surgery, University Hospital Brno, Brno, Czechia; RECETOX, Faculty of Science, Masaryk University, Brno, Czechia

DOI:

https://doi.org/10.2340/aos.v85.46238

Keywords:

Bisphosphonate, alendronate, statin, simvastatin, osteonecrosis

Abstract

This is a comment on the article ‘Bisphosphonate and statin: adverse effects of co-medication on wound healing in in vitro models of periodontal tissues’ https://doi.org/10.2340/aos.v85.45585

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References

Småland-Reksten A, Agger AE, Lian AM, Reseland JE, Krüger TB. Bisphosphonate and statin: adverse effects of co-medication on wound healing in in vitro models of periodontal tissues. Acta Odontol Scand. 2026;85:125–33. DOI: https://doi.org/10.2340/aos.v85.45585

Száraz D, Peřina V, Treglerová J, Macháček C, Zendulka O, Bořilová Linhartová P. Case Report: single low-dose of denosumab as a trigger of MRONJ development in a patient with osteoporosis after bisphosphonate therapy. Front Oral Health. 2024;5:1473049. DOI: https://doi.org/10.3389/froh.2024.1473049

Aghaloo TL, Tetradis S. Osteonecrosis of the jaw in the absence of antiresorptive or antiangiogenic exposure: a series of 6 cases. J Oral Maxillofac Surg. 2017;75:129–42. DOI: https://doi.org/10.1016/j.joms.2016.07.019

Nordin J, Ghazali AB. Osteonecrosis of the jaw in patients taking Atorvastatin: case series. IJOHS. 2022;3:219–22. DOI: https://doi.org/10.31436/ijohs.v3i2.73

Giladi HZ, Gabay E, Machtei EE. Medication-related osteonecrosis of the jaw in patients taking high-dose simvastatin. J Oral Maxillofac Surg. 2020;78:862–3. DOI: https://doi.org/10.1016/j.joms.2020.01.009

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Bae E-B, Kim M-Y, Ji S, Cho I-W, Kim SY, Esmaeili M, et al. Anti-VEGF neutralizing antibody delays osteomucosal healing by reducing collagen formation in mice. Sci Rep. 2025;15:36903. DOI: https://doi.org/10.1038/s41598-025-20840-x

Tan J, Yang N, Fu X, Cui Y, Guo Q, Ma T, et al. Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model. Med Sci Monit. 2015;21:1428–39. DOI: https://doi.org/10.12659/MSM.892247

Adachi N, Ayukawa Y, Yasunami N, Furuhashi A, Imai M, Sanda K, et al. Preventive effect of fluvastatin on the development of medication-related osteonecrosis of the jaw. Sci Rep. 2020;10:5620. DOI: https://doi.org/10.1038/s41598-020-61724-6

Yasunami N, Ayukawa Y, Furuhashi A, Atsuta I, Rakhmatia YD, Moriyama Y, et al. Acceleration of hard and soft tissue healing in the oral cavity by a single transmucosal injection of fluvastatin-impregnated poly (lactic-co-glycolic acid) microspheres. An in vitro and rodent in vivo study. Biomed Mater. 2015;11:015001. DOI: https://doi.org/10.1088/1748-6041/11/1/015001

Published

2026-06-10

Issue

Section

Letter to the Editor