Adult Spasticity International Registry Study: methodology and baseline patient, healthcare provider, and caregiver characteristics
DOI:
https://doi.org/10.2340/16501977-2245Keywords:
onabotulinumtoxinA, muscle spasticity, research methodology, botulinum toxin, Type A, ASPIRE, baseline characteristics.Abstract
Objective: The main aim of this study was to determine the utilization patterns and effectiveness of onabotulinumtoxinA (Botox?) for treatment of spasticity in clinical practice. Design: An international, multicentre, prospective, observational study at selected sites in North America, Europe, and Asia. Patients: Adult patients with newly diagnosed or established focal spasticity, including those who had previously received treatment with onabotulinum-toxin A. Methods: Patients were treated with onabotulinumtoxinA, approximately every 12 weeks, according to their physician?s usual clinical practice over a period of up to 96 weeks, with a final follow-up interview at 108 weeks. Patient, physician and caregiver data were collected. Results: Baseline characteristics are reported. Of the 745 patients enrolled by 75 healthcare providers from 54 sites, 474 patients had previously received onabotulinumtoxinA treatment for spasticity. Lower limb spasticity was more common than upper limb spasticity, with stroke the most common underlying aetiology. The Short-Form 12 (SF-12) health survey scores showed that patients? spasticity had a greater perceived impact on physical rather than mental aspects. Conclusion: The data collected in this study will guide the development of administration strategies to optimize the effectiveness of onabotulinumtoxinA in the management of spasticity of various underlying aetiologies.Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Gerard E. Francisco, Daniel S. Bandari, Ganesh Bavikatte, Wolfgang H. Jost, Aubrey Manack Adams, Joan Largent, Alberto Esquenazi
![Creative Commons License](http://i.creativecommons.org/l/by-nc/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized JRM contents is available freely online. The Foundation for Rehabilitation Medicine owns the copyright for all material published until volume 40 (2008), as from volume 41 (2009) authors retain copyright to their work and as from volume 49 (2017) the journal has been published Open Access, under CC-BY-NC licences (unless otherwise specified). The CC-BY-NC licenses allow third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
From 2024, articles are published under the CC-BY licence. This license permits sharing, adapting, and using the material for any purpose, including commercial use, with the condition of providing full attribution to the original publication.