Fatigue is Associated with Reduced Participation and Health-Related Quality of Life Five Years After Perimesencephalic Subarachnoid Haemorrhage: A Multicentre Cross-Sectional Study

Authors

  • Elisabeth A. de Vries Erasmus MC, University Medical Center Rotterdam, Department of Rehabilitation Medicine; Rijndam Rehabilitation, Rotterdam, The Netherlands
  • Wendy Boerboom Rijndam Rehabilitation, Rotterdam, The Netherlands
  • Rita J.G. van den Berg-Emons Erasmus MC, University Medical Center Rotterdam, Department of Rehabilitation Medicine
  • Fop van Kooten Erasmus MC, University Medical Center Rotterdam, Department of Neurology
  • Johanna M.A. Visser-Meily Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Center, University Medical Center Utrecht; Center of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht and De Hoogstraat Rehabilitation, Utrecht, The Netherlands
  • Gerard M. Ribbers Erasmus MC, University Medical Center Rotterdam, Department of Rehabilitation Medicine; Rijndam Rehabilitation, Rotterdam, The Netherlands
  • Majanka H. Heijenbrok-Kal Erasmus MC, University Medical Center Rotterdam, Department of Rehabilitation Medicine; Rijndam Rehabilitation, Rotterdam, The Netherlands

DOI:

https://doi.org/10.2340/jrm.v54.212

Keywords:

Fatigue, Participation, Health-related quality of life, Mood, Coping, Perimesencephalic subarachnoid hemorrhage, Stroke, Subarachnoid Hemorrhage

Abstract

Objective: To determine whether fatigue is associated with participation and health-related quality of life 5 years after perimesencephalic subarachnoid haemorrhage.
Design: Multicentre cross-sectional study.
Subjects: Forty-six patients with perimesencephalic subarachnoid haemorrhage.
Methods: Fatigue was assessed with the Fatigue Severity Scale, participation (frequency, restrictions, satisfaction) with the Utrecht Scale for Evaluation of Rehabilitation-Participation, healthrelated quality of life with the Stroke-Specific Quality of Life Scale-12, symptoms of depression and anxiety with the Hospital Anxiety and Depression Scale, and coping with the Coping Inventory for Stressful Situations.
Results: A total of 46 patients were included (63% men, mean age 50.4 ± 9.4 years), with a mean time of 4.7 ± 1.6 years after perimesencephalic subarachnoid haemorrhage onset. Fatigued patients (33%) had worse participation (p < 0.01) and health-related quality of life (p < 0.001) than non-fatigued patients, and more often had hypertension, depression, anxiety and emotion-oriented coping (p < 0.05). Fatigue severity was inversely and independently (p < 0.005) associated with participation frequency (B = –3.62), satisfaction (B = –4.54), having restrictions (odds ratio = 2.48, 95% confidence interval 1.079–5.685), and health-related quality of life (B = –0.19), adjusted for depression, anxiety, and/or hypertension.
Conclusion: Five years after perimesencephalic subarachnoid haemorrhage, one-third of patients still reported fatigue, which was associated with worse participation and health-related quality of life. Future studies should examine whether these patients may benefit from rehabilitation aimed at fatigue.

LAY ABSTRACT
A subarachnoid haemorrhage (SAH) is a subtype of stroke. Of all patients with SAH, approximately 10% are diagnosed with non-aneurysmal perimesencephalic subarachnoid haemorrhage (PM-SAH). PM-SAH is generally considered a benign form of SAH; however we have previously found that one-third of patients with PM-SAH are still fatigued 5 years after PM-SAH. Fatigue may be related to reduced participation and health-related quality of life, both of which are considered important rehabilitation outcomes. Therefore, this study examined whether fatigue is associated with participation and health-related quality of life after PM-SAH. The results showed that, 5 years after PM-SAH, fatigued patients had worse participation and quality of life than non-fatigued patients. In addition, more severe fatigue was associated with worse participation, regarding frequency, satisfaction and restrictions, and with worse health-related quality of life. Further studies are necessary to determine whether patients with PM-SAH may benefit from rehabilitation aimed at fatigue.

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Published

2022-05-11

How to Cite

de Vries, E. A., Boerboom, W., van den Berg-Emons, R. J., van Kooten, F., Visser-Meily, J. M., Ribbers, G. M., & Heijenbrok-Kal, M. H. (2022). Fatigue is Associated with Reduced Participation and Health-Related Quality of Life Five Years After Perimesencephalic Subarachnoid Haemorrhage: A Multicentre Cross-Sectional Study. Journal of Rehabilitation Medicine, 54, jrm00271. https://doi.org/10.2340/jrm.v54.212

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