Coupling auditory cues and bilateral transauricular vagus nerve stimulation in Parkinson’s disease with freezing of gait: an open-label feasibility study

Authors

  • Andrea Di Maio Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
  • Mario Meloni Neurology Unit, Azienda Ospedaliera Universitaria di Cagliari, Cagliari, Italy
  • Jae-Jun Song Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Guro Hospital, Seoul, Korea; Institute for Health Care Convergence Center, Korea University Guro Hospital, Seoul, Korea; Neurive Institute, Neurive Co., Ltd., Seoul, Korea
  • Vincenzo Di Lazzaro Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
  • Massimo Marano Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy

DOI:

https://doi.org/10.2340/jrm.v58.45165

Keywords:

Parkinson's disease, brain stimulation, Falls, freezing of gait

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References

Tosserams A, Fasano A, Gilat M, Factor SA, Giladi N, Lewis SJG, et al. Management of freezing of gait: mechanism-based practical recommendations. Nat Rev Neurol 2025; 21: 327–344. DOI: https://doi.org/10.1038/s41582-025-01079-6

https://doi.org/10.1038/s41582-025-01079-6 DOI: https://doi.org/10.1038/s41582-025-01079-6

Chou KL, Kanel P, van Emde Boas M, Roytman S, Carli G, Albin RL, et al. Cholinergic system changes in dopa-unresponsive freezing of gait in Parkinson’s disease. Mov Disord 2025; 40: 1584–1594. DOI: https://doi.org/10.1002/mds.30196

https://doi.org/10.1002/mds.30196 DOI: https://doi.org/10.1002/mds.30196

Delgado-Alvarado M, Marano M, Santurtún A, Urtiaga-Gallano A, Tordesillas-Gutierrez D, Infante J. Nonpharmacological, nonsurgical treatments for freezing of gait in Parkinson’s disease: a systematic review. Mov Disord 2020; 35: 204–214. DOI: https://doi.org/10.1002/mds.27913

https://doi.org/10.1002/mds.27913 DOI: https://doi.org/10.1002/mds.27913

Cioni M, Amata O, Seminara MR, Marano P, Palermo F, Corallo V, et al. Responsiveness to sensory cues using the Timed Up and Go test in patients with Parkinson’s disease: a prospective cohort study. J Rehabil Med 2015; 47: 824–829. DOI: https://doi.org/10.2340/16501977-2003

https://doi.org/10.2340/16501977-2003 DOI: https://doi.org/10.2340/16501977-2003

Matsuoka M, Yamaguchi T, Fujiwara T. Transcutaneous auricular vagus nerve stimulation in healthy individuals, stroke, and Parkinson’s disease: a narrative review of safety, parameters, and efficacy. Front Physiol 2025; 16: 1693907. DOI: https://doi.org/10.3389/fphys.2025.1693907

https://doi.org/10.3389/fphys.2025.1693907 DOI: https://doi.org/10.3389/fphys.2025.1693907

Marano M, Anzini G, Musumeci G, Magliozzi A, Pozzilli V, Capone F, et al. Transcutaneous auricular vagus stimulation improves gait and reaction time in Parkinson’s disease. Mov Disord 2022; 37: 2163–2164. DOI: https://doi.org/10.1002/mds.29166

https://doi.org/10.1002/mds.29166 DOI: https://doi.org/10.1002/mds.29166

Shan J, Li Z, Ji M, Zhang M, Zhang C, Zhu Y, et al. Transcutaneous vagus nerve stimulation for Parkinson’s disease: a systematic review and meta-analysis. Front Aging Neurosci 2025; 16: 1498176. DOI: https://doi.org/10.3389/fnagi.2024.1498176

https://doi.org/10.3389/fnagi.2024.1498176 DOI: https://doi.org/10.3389/fnagi.2024.1498176

Mondal B, Choudhury S, Simon B, Baker MR, Kumar H. Noninvasive vagus nerve stimulation improves gait and reduces freezing of gait in Parkinson’s disease. Mov Disord 2019; 34: 917–918. DOI: https://doi.org/10.1002/mds.27662

https://doi.org/10.1002/mds.27662 DOI: https://doi.org/10.1002/mds.27662

Morris R, Yarnall AJ, Hunter H, Taylor JP, Baker MR, Rochester L. Noninvasive vagus nerve stimulation to target gait impairment in Parkinson’s disease. Mov Disord 2019; 34: 918–919. DOI: https://doi.org/10.1002/mds.27664

https://doi.org/10.1002/mds.27664 DOI: https://doi.org/10.1002/mds.27664

Nieuwboer A, Rochester L, Herman T, Vandenberghe W, Emil GE, Thomaes T, et al. Reliability of the new freezing of gait questionnaire: agreement between patients with Parkinson’s disease and their carers. Gait Posture 2009; 30: 459–463. DOI: https://doi.org/10.1016/j.gaitpost.2009.07.108

Lavigne SK, Burdette JH, Bahrami M, Laurienti PJ, Lyday RG, Thaut MH. Altered basal ganglia network topology associated with auditory-motor synchronization. Brain Behav 2025; 15: e70695. DOI: https://doi.org/10.1002/brb3.70695

https://doi.org/10.1002/brb3.70695 DOI: https://doi.org/10.1002/brb3.70695

arrison EC, Grossen S, Tueth LE, Haussler AM, Rawson KS, Campbell MC, et al. Neural mechanisms underlying synchronization of movement to musical cues in Parkinson disease and aging. Front Neurosci 2025; 19: 1550802. DOI: https://doi.org/10.3389/fnins.2025.1550802

https://doi.org/10.3389/fnins.2025.1550802 DOI: https://doi.org/10.3389/fnins.2025.1550802

Engineer ND, Riley JR, Seale JD, Vrana WA, Shetake JA, Sudanagunta SP, et al. Reversing pathological neural activity using targeted plasticity. Nature 2011; 470: 101–104. DOI: https://doi.org/10.1038/nature09656

https://doi.org/10.1038/nature09656 DOI: https://doi.org/10.1038/nature09656

Bosch TJ, Barsainya R, Ridder A, Santosh KC, Singh A. Interval timing and midfrontal delta oscillations are impaired in Parkinson’s disease patients with freezing of gait. J Neurol 2022; 269: 2599–2609. DOI: https://doi.org/10.1007/s00415-021-10843-9

https://doi.org/10.1007/s00415-021-10843-9 DOI: https://doi.org/10.1007/s00415-021-10843-9

Camargo L, Gianlorenço AC, Pacheco-Barrios K, Pichardo E, Costa V, Choi H, et al. The effects of non-invasive transcutaneous auricular vagus nerve stimulation on resting-state delta oscillation: a randomized, double-blinded, sham-control trial. Sci Rep 2025: 34531. DOI: https://doi.org/10.1038/s41598-025-17821-5

https://doi.org/10.1038/s41598-025-17821-5 DOI: https://doi.org/10.1038/s41598-025-17821-5

Additional Files

Published

2026-03-04

How to Cite

Di Maio, A., Meloni, M., Song, J.-J., Di Lazzaro, V., & Marano, M. (2026). Coupling auditory cues and bilateral transauricular vagus nerve stimulation in Parkinson’s disease with freezing of gait: an open-label feasibility study. Journal of Rehabilitation Medicine, 58, jrm45165. https://doi.org/10.2340/jrm.v58.45165

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