Treat-to-Target in Atopic Dermatitis: An International Consensus on a Set of Core Decision Points for Systemic Therapies

Authors

  • Marjolein S. De Bruin-Weller National Expertise Center of Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
  • Tilo Biedermann
  • Robert Bissonnette
  • Mette Deleuran
  • Peter Foley
  • Giampiero Girolomoni
  • Jana Hercogová
  • Chih-Ho Hong
  • Norito Katoh
  • Andrew E. Pink
  • Marie-Aleth Richard
  • Stephen Shumack
  • Juan F. Silvestre
  • Stephan Weidinger

DOI:

https://doi.org/10.2340/00015555-3751

Keywords:

atopic dermatitis, eDelphi, consensus, surveys and questionnaires, treat-to-target, systemic treatment

Abstract

Currently no treat-to-target framework to guide systemic treatment in adults with moderate-to-severe atopic dermatitis exists. We sought to reach international consensus through an eDelphi process on a core set of recommendations for such an approach. Recommendations were developed by an international Steering Committee, spanning 3 areas (Guiding Principles, Decision Making, and Outcome Thresholds) and 2 specific time-points; an initial acceptable target at 3 months and an optimal target at 6 months, each based on improvements in patient global assessment plus at least one specific outcome domain. These treat-to-target- orientated recommendations were evaluated by an extended international panel of physicians, nurses and patients. Proposed recommendations were rated using a 9-point Likert scale; for each recommendation, consensus agreement was reached if ≥ 75% of all respondents rated agreement as ≥ 7. Consensus on 16 core recommendations was reached over 2 eDelphi rounds. These provide a framework for shared decision-making on systemic treatment continuation, modification, or discontinuation.

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References

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Additional Files

Published

2021-02-17

How to Cite

De Bruin-Weller, M. S., Biedermann, T., Bissonnette, R., Deleuran, M., Foley, P., Girolomoni, G., Hercogová, J., Hong, C.-H., Katoh, N., Pink, A. E., Richard, M.-A., Shumack, S., Silvestre, . J. F., & Weidinger, S. (2021). Treat-to-Target in Atopic Dermatitis: An International Consensus on a Set of Core Decision Points for Systemic Therapies. Acta Dermato-Venereologica, 101(2), adv00402. https://doi.org/10.2340/00015555-3751