Immunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin
DOI:
https://doi.org/10.1080/00015550410035506Abstract
Psoriasis responds favourably to treatment with retinoids but the cellular pathways mediating these effects are poorly understood. Retinoids regulate keratinocyte proliferation and maturation via binding to nuclear retinoic acid receptors (mainly RARalpha and RARgamma) which form heterodimers with the 9-cis-RA receptor, RXRalpha. We have previously shown that mRNA expression of RARalpha and RXRalpha is down-regulated in psoriatic lesions as compared with non-lesional human skin. In the present study, we investigated the protein expression of RARalpha, RARgamma and RXRalpha in normal and psoriatic skin using indirect immunofluorescence analysis. Epidermal keratinocytes of normal and non-lesional psoriatic skin displayed similar nuclear localization of all three receptorsDownloads
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Published
2004-09-17
How to Cite
Karlsson T, R. O. (2004). Immunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin. Acta Dermato-Venereologica, 84(5), 363–369. https://doi.org/10.1080/00015550410035506
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