Lichen Simplex Chronicus Itch: An Update


  • Teresa Ju University of Miami Miller School of Medicine
  • Ashley Vander Does
  • Noreen Mohsin
  • Gil Yosipovitch Dr Phillip Frost Department of Dermatology, University of Miami, 1150 NW 14th St, Miami, FL 33136, USA



itch, lichen simplex chronicus, physiopathology, pruritus


Lichen simplex chronicus is a form of chronic localized pruritus with a secondary dermatitis, and one of the most common types of chronic itch conditions, estimated to affect more than 10% of the general population. However, despite its prevalence and burden, there has been limited research into the pathogenesis and aetiology of lichen simplex chronicus, which, historically, made it a challenging condition to treat. In recent years, our understanding of this condition, along with that of pruritus and the itch-scratch cycle, has increased greatly, enabling a substantial increase in treatment options. In addition, there are several new promising treatments currently in development and trials. This article discusses the definition, epidemiology, clinical characteristics, pathophysiology, and current therapeutic options for lichen simplex chronicus, in order to highlight recent advancements in this field.


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How to Cite

Ju, T., Vander Does, A., Mohsin, N., & Yosipovitch, G. . (2022). Lichen Simplex Chronicus Itch: An Update. Acta Dermato-Venereologica, 102, adv00796.

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